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10.1038/cdd.2015.149 http://scihub22266oqcxt.onion/10.1038/cdd.2015.149 C4832104!4832104!26586568     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2016 ; 23 (5): 853-64 Nephropedia Template TP {{tp|p=26586568|t=2016. Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses |pdf=|usr=}}{{26586568}} gab.com Text Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26586568 #FOAvip To gain new insight into the role of B-cell autophagy, we generated two novel mouse models deficient for the autophagy-related gene (Atg)5, one from the outset pro-B cell stage (Atg5f/? Mb1 cre) and the other in mature B cells only (Atg5f/? CD21 cre). We show that autophagy is dispensable for pro- to pre-B cell transition, but necessary at a basal level to maintain normal numbers of peripheral B cells. It appears non-essential for B-cell activation under B-cell receptor stimulation but required for their survival after lipopolysaccharide stimulation that drives plasmablast differentiation and for specific IgM production after immunization. Results obtained using Atg5f/? CD21 cre × C57BL/6lpr/lpr autoimmune-prone mice show that B-cell autophagy is involved in the maintenance of anti-nuclear antibody secretion, elevated number of long-lived plasma cells, and sustains IgG deposits in the kidneys. Thus, treatments specifically targeting autophagy might be beneficial in systemic autoimmune diseases. Twit Text FOAVip Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26586568 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26586568 #FOAvip English Wikipedia <ref>{{Cite pmid|26586568}}</ref> Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses #MMPMID26586568 Arnold J; Murera D; Arbogast F; Fauny JD; Muller S; Gros F Cell Death Differ 2016[May]; 23 (5): 853-64 PMID26586568show ga To gain new insight into the role of B-cell autophagy, we generated two novel mouse models deficient for the autophagy-related gene (Atg)5, one from the outset pro-B cell stage (Atg5f/? Mb1 cre) and the other in mature B cells only (Atg5f/? CD21 cre). We show that autophagy is dispensable for pro- to pre-B cell transition, but necessary at a basal level to maintain normal numbers of peripheral B cells. It appears non-essential for B-cell activation under B-cell receptor stimulation but required for their survival after lipopolysaccharide stimulation that drives plasmablast differentiation and for specific IgM production after immunization. Results obtained using Atg5f/? CD21 cre × C57BL/6lpr/lpr autoimmune-prone mice show that B-cell autophagy is involved in the maintenance of anti-nuclear antibody secretion, elevated number of long-lived plasma cells, and sustains IgG deposits in the kidneys. Thus, treatments specifically targeting autophagy might be beneficial in systemic autoimmune diseases. äAutophagy is dispensable for B-cell development but essential for humo(epmc).pdf DeepDyve Pubget Overpricing