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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Hematol+Malig+Rep
2013 ; 8
(3
): 173-83
Nephropedia Template TP
gab.com Text
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English Wikipedia
Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and
current treatment strategies
#MMPMID23737188
Al-Mansour Z
; Nelson BP
; Evens AM
Curr Hematol Malig Rep
2013[Sep]; 8
(3
): 173-83
PMID23737188
show ga
Post-transplant lymphoproliferative diseases (PTLD) are heterogeneous lymphoid
disorders ranging from indolent polyclonal proliferations to aggressive lymphomas
that complicate solid organ or hematopoietic transplantation. Risk factors for
PTLD include viral infections, degree of immunosuppression, recipient age and
race, allograft type, and host genetic variations. Clinically, extra-nodal
disease is common including 10-15 % presenting with central nervous system (CNS)
disease. Most PTLD cases are B cell (5-10 % T/NK cell or Hodgkin lymphoma), while
over one-third are EBV-negative. World Health Organization (WHO) diagnostic
categories are: early lesions, polymorphic, and monomorphic PTLD; although in
practice, a clear separation is not always possible. Therapeutically, reduction
in immunosuppression remains a mainstay, and recent data has documented the
importance of rituximab +/- combination chemotherapy. Therapy for primary CNS
PTLD should be managed according to immunocompetent CNS paradigms. Finally, novel
treatment strategies for PTLD have emerged, including adoptive immunotherapy and
rational targeted therapeutics (e.g., anti-CD30 based therapy and downstream
signaling pathways of latent membrane protein-2A).