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10.1111/jcmm.12806 http://scihub22266oqcxt.onion/10.1111/jcmm.12806 C4831369!4831369!26931745     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2016 ; 20 (5): 930-8 Nephropedia Template TP {{tp|p=26931745|t=2016. Atopic dermatitis induces the expansion of thymus?derived regulatory T cells exhibiting a Th2?like phenotype in mice |pdf=|usr=}}{{26931745}} gab.com Text Atopic dermatitis induces the expansion of thymus derived regulatory T cells exhibiting a Th2 like phenotype in mice JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26931745 #FOAvip Atopic dermatitis (AD) is a widespread inflammatory skin disease with an early onset, characterized by pruritus, eczematous lesions and skin dryness. This chronic relapsing disease is believed to be primarily a result of a defective epidermal barrier function associated with genetic susceptibility, immune hyper?responsiveness of the skin and environmental factors. Although the important role of abnormal immune reactivity in the pathogenesis of AD is widely accepted, the role of regulatory T cells (Tregs) remains elusive. We found that the Treg population is expanded in a mouse model of AD, i.e. mice topically treated with vitamin D3 (VitD). Moreover, mice with AD?like symptoms exhibit increased inducible T?cell costimulator (ICOS)?, cytotoxic T?lymphocyte antigen?4 (CTLA?4)? and Glycoprotein?A repetitions predominant receptor (GARP)?expressing Tregs in skin?draining lymph nodes. Importantly, the differentiation of Tregs into thymus?derived Tregs is favoured in our mouse model of AD. Emigrated skin?derived dendritic cells are required for Treg induction and Langerhans cells are responsible for the biased expansion of thymus?derived Tregs. Intriguingly, thymus?derived Tregs isolated from mice with AD?like symptoms exhibit a Th2 cytokine profile. Thus, AD might favour the expansion of pathogenic Tregs able to produce Th2 cytokines and to promote the disease instead of alleviating symptoms. Twit Text FOAVip Atopic dermatitis induces the expansion of thymus derived regulatory T cells exhibiting a Th2 like phenotype in mice ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26931745 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26931745 #FOAvip English Wikipedia <ref>{{Cite pmid|26931745}}</ref> Atopic dermatitis induces the expansion of thymus?derived regulatory T cells exhibiting a Th2?like phenotype in mice #MMPMID26931745 Moosbrugger?Martinz V; Tripp CH; Clausen BE; Schmuth M; Dubrac S J Cell Mol Med 2016[May]; 20 (5): 930-8 PMID26931745show ga Atopic dermatitis (AD) is a widespread inflammatory skin disease with an early onset, characterized by pruritus, eczematous lesions and skin dryness. This chronic relapsing disease is believed to be primarily a result of a defective epidermal barrier function associated with genetic susceptibility, immune hyper?responsiveness of the skin and environmental factors. Although the important role of abnormal immune reactivity in the pathogenesis of AD is widely accepted, the role of regulatory T cells (Tregs) remains elusive. We found that the Treg population is expanded in a mouse model of AD, i.e. mice topically treated with vitamin D3 (VitD). Moreover, mice with AD?like symptoms exhibit increased inducible T?cell costimulator (ICOS)?, cytotoxic T?lymphocyte antigen?4 (CTLA?4)? and Glycoprotein?A repetitions predominant receptor (GARP)?expressing Tregs in skin?draining lymph nodes. Importantly, the differentiation of Tregs into thymus?derived Tregs is favoured in our mouse model of AD. Emigrated skin?derived dendritic cells are required for Treg induction and Langerhans cells are responsible for the biased expansion of thymus?derived Tregs. Intriguingly, thymus?derived Tregs isolated from mice with AD?like symptoms exhibit a Th2 cytokine profile. Thus, AD might favour the expansion of pathogenic Tregs able to produce Th2 cytokines and to promote the disease instead of alleviating symptoms. äAtopic dermatitis induces the expansion of thymus?derived regulatory T(epmc).pdf DeepDyve Pubget Overpricing