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suck abstract from ncbi


10.1016/j.ccell.2016.03.010

http://scihub22266oqcxt.onion/10.1016/j.ccell.2016.03.010
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C4831138!4831138!27070700
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suck abstract from ncbi

pmid27070700      Cancer+Cell 2016 ; 29 (4): 452-63
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  • Long Noncoding RNAs in Cancer Pathways #MMPMID27070700
  • Schmitt AM; Chang HY
  • Cancer Cell 2016[Apr]; 29 (4): 452-63 PMID27070700show ga
  • Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.
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