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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Nephrol
2016 ; 29
(2
): 211-219
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Treatment effect, adherence, and safety of high fluid intake for the prevention
of incident and recurrent kidney stones: a systematic review and meta-analysis
#MMPMID26022722
Cheungpasitporn W
; Rossetti S
; Friend K
; Erickson SB
; Lieske JC
J Nephrol
2016[Apr]; 29
(2
): 211-219
PMID26022722
show ga
BACKGROUND: The objective of this systematic review and meta-analysis were to
evaluate the effectiveness of high fluid intake for the prevention of incident
and recurrent kidney stones, as well as its adherence and safety. METHODS: A
literature search was performed encompassing 1980 through July 2014. Studies that
reported relative risks, odds ratios, or hazard ratios comparing the risk of
kidney stone events in patients with high vs inadequate fluid intake were
included. Pooled risk ratios (RRs) and 95 % confidence intervals (CIs) were
calculated using a random-effect, generic inverse variance method. RESULTS: Nine
studies [2 randomized controlled trials (RCTs) with 269 patients; 7 observational
studies with 273,685 individuals] were included in the meta-analysis. Pooled RRs
of kidney stones in individuals with high-fluid intake were 0.40 (95 % CI
0.20-0.79) and 0.49 (0.34-0.71) in RCTs and observational studies, respectively.
High fluid intake was significantly associated with reduced risk of recurrent
kidney stones: RRs 0.40 (95 % CI 0.20-0.79) and 0.20 (0.09-0.44) in RCTs and
observational studies, respectively. Adherence and safety data on high fluid
intake treatment were limited; 1 RCT reported no withdrawals due to adverse
events. CONCLUSION: This analysis demonstrated a significantly reduced risk of
incident kidney stones among individuals with high fluid consumption. High fluid
consumption also reduced the risk of recurrent kidney stones. Furthermore, the
magnitude of risk reduction was high. Although increased water intake appears to
be safe, future studies on its safety in patients with high risk of volume
overload or hyponatremia may be indicated.
|*Drinking
[MESH]
|*Patient Compliance
[MESH]
|Chi-Square Distribution
[MESH]
|Female
[MESH]
|Fluid Therapy/adverse effects/*methods
[MESH]
|Humans
[MESH]
|Incidence
[MESH]
|Kidney Calculi/diagnosis/epidemiology/physiopathology/*prevention & control
[MESH]