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10.1371/journal.pone.0153434 http://scihub22266oqcxt.onion/10.1371/journal.pone.0153434 C4830567!4830567 !27073902     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27073902 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2016 ; 11 (4 ): e0153434 Nephropedia Template TP {{tp|p=27073902 |t=2016. Post-Natal Inhibition of NF-?B Activation Prevents Renal Damage Caused by Prenatal LPS Exposure |pdf=|usr=}}{{27073902 }} gab.com Text Post-Natal Inhibition of NF- B Activation Prevents Renal Damage Caused by Prenatal LPS Exposure JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27073902 #FOAvip Prenatal exposure to an inflammatory stimulus has been shown to cause renal damage in offspring. Our present study explored the role of intra-renal NF-?B activation in the development of progressive renal fibrosis in offspring that underwent prenatal exposure to an inflammatory stimulus. Time-dated pregnant rats were treated with saline (control group) or 0.79 mg/kg lipopolysaccharide (LPS) through intra-peritoneal injection on gestational day 8, 10 and 12. At the age of 7 weeks, offspring from control or LPS group were treated with either tap water (Con+Ve or LPS+Ve group) or pyrollidine dithiocarbamate (PDTC, 120 mg/L), a NF-?B inhibitor, via drinking water starting (Con+PDTC or LPS+PDTC group), respectively, till the age of 20 or 68 weeks. The gross structure of kidney was assessed by hematoxylin-eosin, periodic acid-Schiff staining and Sirius red staining. The expression levels of TNF-?, IL-6, ?-smooth muscle actin (?-SMA) and renin-angiotensin system (RAS) genes were determined by real time polymerase chain reaction and/or immunohistochemical staining. Our data showed that post-natal persistent PDTC administration efficiently repressed intra-renal NF-?B activation, TNF-? and IL-6 expression. Post-natal PDTC also prevented intra-renal glycogen deposition and collagenous fiber generation as evident by the reduced expression of collagen III and interstitial ?-SMA in offspring of prenatal LPS exposure. Furthermore, post-natal PDTC administration reversed the intra-renal renin-angiotensin system (RAS) over-activity in offspring of prenatal LPS exposure. In conclusion, prenatal inflammatory exposure results in offspring's intra-renal NF-?B activation along with inflammation which cross-talked with excessive RAS activation that caused exacerbation of renal fibrosis and dysfunction in the offspring. Thus, early life prevention of NF-?B activation may be a potential preventive strategy for chronic renal inflammation and progressive renal damage. Twit Text FOAVip Post-Natal Inhibition of NF- B Activation Prevents Renal Damage Caused by Prenatal LPS Exposure ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27073902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27073902 #FOAvip English Wikipedia <ref>{{Cite pmid|27073902 }}</ref> Post-Natal Inhibition of NF-?B Activation Prevents Renal Damage Caused by Prenatal LPS Exposure #MMPMID27073902 Guo W ; Guan X ; Pan X ; Sun X ; Wang F ; Ji Y ; Huang P ; Deng Y ; Zhang Q ; Han Q ; Yi P ; Namaka M ; Liu Y ; Deng Y ; Li X PLoS One 2016[]; 11 (4 ): e0153434 PMID27073902 show ga Prenatal exposure to an inflammatory stimulus has been shown to cause renal damage in offspring. Our present study explored the role of intra-renal NF-?B activation in the development of progressive renal fibrosis in offspring that underwent prenatal exposure to an inflammatory stimulus. Time-dated pregnant rats were treated with saline (control group) or 0.79 mg/kg lipopolysaccharide (LPS) through intra-peritoneal injection on gestational day 8, 10 and 12. At the age of 7 weeks, offspring from control or LPS group were treated with either tap water (Con+Ve or LPS+Ve group) or pyrollidine dithiocarbamate (PDTC, 120 mg/L), a NF-?B inhibitor, via drinking water starting (Con+PDTC or LPS+PDTC group), respectively, till the age of 20 or 68 weeks. The gross structure of kidney was assessed by hematoxylin-eosin, periodic acid-Schiff staining and Sirius red staining. The expression levels of TNF-?, IL-6, ?-smooth muscle actin (?-SMA) and renin-angiotensin system (RAS) genes were determined by real time polymerase chain reaction and/or immunohistochemical staining. Our data showed that post-natal persistent PDTC administration efficiently repressed intra-renal NF-?B activation, TNF-? and IL-6 expression. Post-natal PDTC also prevented intra-renal glycogen deposition and collagenous fiber generation as evident by the reduced expression of collagen III and interstitial ?-SMA in offspring of prenatal LPS exposure. Furthermore, post-natal PDTC administration reversed the intra-renal renin-angiotensin system (RAS) over-activity in offspring of prenatal LPS exposure. In conclusion, prenatal inflammatory exposure results in offspring's intra-renal NF-?B activation along with inflammation which cross-talked with excessive RAS activation that caused exacerbation of renal fibrosis and dysfunction in the offspring. Thus, early life prevention of NF-?B activation may be a potential preventive strategy for chronic renal inflammation and progressive renal damage. |*Lipopolysaccharides [MESH] |Animals [MESH] |Female [MESH] |Fibrosis/chemically induced/metabolism/pathology/*prevention & control [MESH] |Kidney/*drug effects/metabolism/pathology [MESH] |NF-kappa B/*antagonists & inhibitors [MESH] |Pregnancy [MESH] |Prenatal Exposure Delayed Effects/*metabolism/pathology [MESH] |Pyrrolidines/*pharmacology/therapeutic use [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Signal Transduction/drug effects [MESH]Post-Natal Inhibition of NF-?B Activation Prevents Renal Damage Caused(epmc).pdf DeepDyve Pubget Overpricing