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2016 ; 2016
(ä): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
BRONCO: Biomedical entity Relation ONcology COrpus for extracting
gene-variant-disease-drug relations
#MMPMID27074804
Lee K
; Lee S
; Park S
; Kim S
; Kim S
; Choi K
; Tan AC
; Kang J
Database (Oxford)
2016[]; 2016
(ä): ä PMID27074804
show ga
Comprehensive knowledge of genomic variants in a biological context is key for
precision medicine. As next-generation sequencing technologies improve, the
amount of literature containing genomic variant data, such as new functions or
related phenotypes, rapidly increases. Because numerous articles are published
every day, it is almost impossible to manually curate all the variant information
from the literature. Many researchers focus on creating an improved automated
biomedical natural language processing (BioNLP) method that extracts useful
variants and their functional information from the literature. However, there is
no gold-standard data set that contains texts annotated with variants and their
related functions. To overcome these limitations, we introduce a Biomedical
entity Relation ONcology COrpus (BRONCO) that contains more than 400 variants and
their relations with genes, diseases, drugs and cell lines in the context of
cancer and anti-tumor drug screening research. The variants and their relations
were manually extracted from 108 full-text articles. BRONCO can be utilized to
evaluate and train new methods used for extracting biomedical entity relations
from full-text publications, and thus be a valuable resource to the biomedical
text mining research community. Using BRONCO, we quantitatively and qualitatively
evaluated the performance of three state-of-the-art BioNLP methods. We also
identified their shortcomings, and suggested remedies for each method. We
implemented post-processing modules for the three BioNLP methods, which improved
their performance.Database URL:http://infos.korea.ac.kr/bronco.