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10.1016/j.cell.2016.02.047 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.02.047 C4830124!4830124!26967284     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 164 (6): 1172-84 Nephropedia Template TP {{tp|p=26967284|t=2016. The Dark Side of Cell Signaling: Positive Roles for Negative Regulators |pdf=|usr=}}{{26967284}} gab.com Text The Dark Side of Cell Signaling: Positive Roles for Negative Regulators JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26967284 #FOAvip Cell signaling is dominated by analyzing positive responses to stimuli. Signal activation is balanced by negative regulators that are generally considered to terminate signaling. Rather than exerting only negative effects, however, many such regulators play important roles in enhancing cell-signaling control. Considering responses downstream of selected cell-surface receptors, we discuss how receptor internalization affects signaling specificity and how rapid kinase/phosphatase and GTP/GDP cycles increase responsiveness and allow kinetic proofreading in receptor signaling. We highlight the blurring of distinctions between positive and negative signals, recasting signal termination as the response to a switch-like transition into a new cellular state. Twit Text FOAVip The Dark Side of Cell Signaling: Positive Roles for Negative Regulators ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26967284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26967284 #FOAvip English Wikipedia <ref>{{Cite pmid|26967284}}</ref> The Dark Side of Cell Signaling: Positive Roles for Negative Regulators #MMPMID26967284 Lemmon MA; Freed DM; Schlessinger J; Kiyatkin A Cell 2016[Mar]; 164 (6): 1172-84 PMID26967284show ga Cell signaling is dominated by analyzing positive responses to stimuli. Signal activation is balanced by negative regulators that are generally considered to terminate signaling. Rather than exerting only negative effects, however, many such regulators play important roles in enhancing cell-signaling control. Considering responses downstream of selected cell-surface receptors, we discuss how receptor internalization affects signaling specificity and how rapid kinase/phosphatase and GTP/GDP cycles increase responsiveness and allow kinetic proofreading in receptor signaling. We highlight the blurring of distinctions between positive and negative signals, recasting signal termination as the response to a switch-like transition into a new cellular state. äThe Dark Side of Cell Signaling: Positive Roles for Negative Regulator(epmc).pdf DeepDyve Pubget Overpricing