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10.1038/ng.3444 http://scihub22266oqcxt.onion/10.1038/ng.3444 C4829974!4829974 !26551670     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26551670 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Genet 2015 ; 47 (12 ): 1426-34 Nephropedia Template TP {{tp|p=26551670 |t=2015. Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes |pdf=|usr=}}{{26551670 }} gab.com Text Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=26551670 #FOAvip Sézary syndrome is a rare leukemic form of cutaneous T cell lymphoma characterized by generalized redness, scaling, itching and increased numbers of circulating atypical T lymphocytes. It is rarely curable, with poor prognosis. Here we present a multiplatform genomic analysis of 37 patients with Sézary syndrome that implicates dysregulation of cell cycle checkpoint and T cell signaling. Frequent somatic alterations were identified in TP53, CARD11, CCR4, PLCG1, CDKN2A, ARID1A, RPS6KA1 and ZEB1. Activating CCR4 and CARD11 mutations were detected in nearly one-third of patients. ZEB1, encoding a transcription repressor essential for T cell differentiation, was deleted in over one-half of patients. IL32 and IL2RG were overexpressed in nearly all cases. Our results demonstrate profound disruption of key signaling pathways in Sézary syndrome and suggest potential targets for new therapies. Twit Text FOAVip Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=26551670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26551670 #FOAvip English Wikipedia <ref>{{Cite pmid|26551670 }}</ref> Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes #MMPMID26551670 Wang L ; Ni X ; Covington KR ; Yang BY ; Shiu J ; Zhang X ; Xi L ; Meng Q ; Langridge T ; Drummond J ; Donehower LA ; Doddapaneni H ; Muzny DM ; Gibbs RA ; Wheeler DA ; Duvic M Nat Genet 2015[Dec]; 47 (12 ): 1426-34 PMID26551670 show ga Sézary syndrome is a rare leukemic form of cutaneous T cell lymphoma characterized by generalized redness, scaling, itching and increased numbers of circulating atypical T lymphocytes. It is rarely curable, with poor prognosis. Here we present a multiplatform genomic analysis of 37 patients with Sézary syndrome that implicates dysregulation of cell cycle checkpoint and T cell signaling. Frequent somatic alterations were identified in TP53, CARD11, CCR4, PLCG1, CDKN2A, ARID1A, RPS6KA1 and ZEB1. Activating CCR4 and CARD11 mutations were detected in nearly one-third of patients. ZEB1, encoding a transcription repressor essential for T cell differentiation, was deleted in over one-half of patients. IL32 and IL2RG were overexpressed in nearly all cases. Our results demonstrate profound disruption of key signaling pathways in Sézary syndrome and suggest potential targets for new therapies. |*Gene Regulatory Networks [MESH] |Case-Control Studies [MESH] |Cell Differentiation/*genetics [MESH] |Exome/genetics [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Genetic Drift [MESH] |Genomics/methods [MESH] |High-Throughput Nucleotide Sequencing/methods [MESH] |Humans [MESH] |Lymphocyte Activation [MESH] |Mutation/*genetics [MESH] |Prognosis [MESH] |Sezary Syndrome/*genetics/mortality/pathology [MESH] |Signal Transduction [MESH] |Skin Neoplasms/*genetics/mortality/pathology [MESH] |Survival Rate [MESH]Genomic profiling of Sézary syndrome identifies alterations of key T c(epmc).pdf DeepDyve Pubget Overpricing