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10.1021/acsami.5b10883 http://scihub22266oqcxt.onion/10.1021/acsami.5b10883 C4829641!4829641 !26894609     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26894609 &cmd=llinks): Failed to open stream: HTTP request failed! 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Approach to Rapid Synthesis and Functionalization of Iron Oxide Nanoparticles for High Gene Transfection |pdf=|usr=}}{{26894609 }} gab.com Text Approach to Rapid Synthesis and Functionalization of Iron Oxide Nanoparticles for High Gene Transfection JO: ACS Appl Mater Interfaces http://www.kidney.de/pget.php?&tw=1&pmid=26894609 #FOAvip Surface functionalization of theranostic nanoparticles (NPs) typically relies on lengthy, aqueous postsynthesis labeling chemistries that have limited ability to fine-tune surface properties and can lead to NP heterogeneity. The need for a rapid, simple synthesis approach that can provide great control over the display of functional moieties on NP surfaces has led to increased use of highly selective bioorthoganol chemistries including metal-affinity coordination. Here we report a simple approach for rapid production of a superparamagnetic iron oxide NPs (SPIONs) with tunable functionality and high reproducibility under aqueous conditions. We utilize the high affinity complex formed between catechol and Fe((III)) as a means to dock well-defined catechol modified polymer modules on the surface of SPIONs during sonochemical coprecipitation synthesis. Polymer modules consisted of chitosan and poly(ethylene glycol) (PEG) copolymer (CP) modified with catechol (CCP), and CCP functionalized with cationic polyethylenimine (CCP-PEI) to facilitate binding and delivery of DNA for gene therapy. This rapid synthesis/functionalization approach provided excellent control over the extent of PEI labeling, improved SPION magnetic resonance imaging (MRI) contrast enhancement and produced an efficient transfection agent. Twit Text FOAVip Approach to Rapid Synthesis and Functionalization of Iron Oxide Nanoparticles for High Gene Transfection ????ACS Appl Mater Interfaces http://www.kidney.de/pget.php?&tw=1&pmid=26894609 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26894609 #FOAvip English Wikipedia <ref>{{Cite pmid|26894609 }}</ref> Approach to Rapid Synthesis and Functionalization of Iron Oxide Nanoparticles for High Gene Transfection #MMPMID26894609 Stephen ZR ; Dayringer CJ ; Lim JJ ; Revia RA ; Halbert MV ; Jeon M ; Bakthavatsalam A ; Ellenbogen RG ; Zhang M ACS Appl Mater Interfaces 2016[Mar]; 8 (10 ): 6320-8 PMID26894609 show ga Surface functionalization of theranostic nanoparticles (NPs) typically relies on lengthy, aqueous postsynthesis labeling chemistries that have limited ability to fine-tune surface properties and can lead to NP heterogeneity. The need for a rapid, simple synthesis approach that can provide great control over the display of functional moieties on NP surfaces has led to increased use of highly selective bioorthoganol chemistries including metal-affinity coordination. Here we report a simple approach for rapid production of a superparamagnetic iron oxide NPs (SPIONs) with tunable functionality and high reproducibility under aqueous conditions. We utilize the high affinity complex formed between catechol and Fe((III)) as a means to dock well-defined catechol modified polymer modules on the surface of SPIONs during sonochemical coprecipitation synthesis. Polymer modules consisted of chitosan and poly(ethylene glycol) (PEG) copolymer (CP) modified with catechol (CCP), and CCP functionalized with cationic polyethylenimine (CCP-PEI) to facilitate binding and delivery of DNA for gene therapy. This rapid synthesis/functionalization approach provided excellent control over the extent of PEI labeling, improved SPION magnetic resonance imaging (MRI) contrast enhancement and produced an efficient transfection agent. |*Coated Materials, Biocompatible/chemistry/pharmacology [MESH] |*Ferric Compounds/chemistry/pharmacology [MESH] |Catechols/chemistry/pharmacology [MESH] |Cell Line, Tumor [MESH] |Genetic Therapy/methods [MESH] |Humans [MESH] |Nanoparticles/*chemistry [MESH] |Polyethylene Glycols/chemistry/pharmacology [MESH] |Polyethyleneimine/chemistry/pharmacology [MESH]Approach to Rapid Synthesis and Functionalization of Iron Oxide Nanopa(epmc).pdf DeepDyve Pubget Overpricing