Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ccell.2016.03.001 http://scihub22266oqcxt.onion/10.1016/j.ccell.2016.03.001 C4829466!4829466!27050099     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Cell 2016 ; 29 (4): 536-47 Nephropedia Template TP {{tp|p=27050099|t=2016. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells |pdf=|usr=}}{{27050099}} gab.com Text N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=27050099 #FOAvip MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We define N-Myc and activated AKT1 as oncogenic components sufficient to transform human prostate epithelial cells to prostate adenocarcinoma and NEPC with phenotypic and molecular features of aggressive, late-stage human disease. We directly show that prostate adenocarcinoma and NEPC can arise from a common epithelial clone. Further, N-Myc is required for tumor maintenance and destabilization of N-Myc through Aurora A kinase inhibition reduces tumor burden. Our findings establish N-Myc as a driver of NEPC and a target for therapeutic intervention. Twit Text FOAVip N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=27050099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27050099 #FOAvip English Wikipedia <ref>{{Cite pmid|27050099}}</ref> N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells #MMPMID27050099 Lee JK; Phillips JW; Smith BA; Park JW; Stoyanova T; McCaffrey EF; Baertsch R; Sokolov A; Meyerowitz JG; Mathis C; Cheng D; Stuart JM; Shokat KM; Gustafson WC; Huang J; Witte ON Cancer Cell 2016[Apr]; 29 (4): 536-47 PMID27050099show ga MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We define N-Myc and activated AKT1 as oncogenic components sufficient to transform human prostate epithelial cells to prostate adenocarcinoma and NEPC with phenotypic and molecular features of aggressive, late-stage human disease. We directly show that prostate adenocarcinoma and NEPC can arise from a common epithelial clone. Further, N-Myc is required for tumor maintenance and destabilization of N-Myc through Aurora A kinase inhibition reduces tumor burden. Our findings establish N-Myc as a driver of NEPC and a target for therapeutic intervention. äN-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prost(epmc).pdf DeepDyve Pubget Overpricing