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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Am+Soc+Hypertens 2016 ; 10 (4): 325-35 Nephropedia Template TP
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Early atherosclerosis aggravates renal microvascular loss and fibrosis in swine renal artery stenosis #MMPMID26879682
Sun D; Eirin A; Ebrahimi B; Textor SC; Lerman A; Lerman LO
J Am Soc Hypertens 2016[Apr]; 10 (4): 325-35 PMID26879682show ga
Background: Renal function in patients with atherosclerosis and renal artery stenosis (ARAS) deteriorates more frequently than in non-atherosclerotic RAS. We hypothesized that ARAS aggravates stenotic kidney microvascular loss compared to RAS. Methods: Domestic pigs were randomized to Normal, RAS, and ARAS (RAS fed a high-cholesterol diet) groups (n=7 each). Ten weeks later stenotic kidney oxygenation, renal blood flow (RBF), and glomerular filtration rate (GFR) were evaluated in-vivo, and microvascular density by Micro-CT. Results: Blood pressure in both RAS and ARAS was elevated, and stenotic kidney RBF and GFR similarly decreased. RAS decreased the density of small-size cortical microvessels (<200 µm), while ARAS extended the decrease to medium-sized microvessels (200?300 µm). Cortical hypoxia and interstitial fibrosis increased in both RAS and ARAS, but correlated inversely with microvascular density only in RAS. Conclusions: Atherosclerosis aggravates loss of stenotic-kidney microvessels, yet additional determinants likely contribute to cortical hypoxia and fibrosis in swine ARAS.