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10.1016/j.jash.2016.01.019

http://scihub22266oqcxt.onion/10.1016/j.jash.2016.01.019
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C4829440!4829440!26879682
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suck abstract from ncbi


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pmid26879682      J+Am+Soc+Hypertens 2016 ; 10 (4): 325-35
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  • Early atherosclerosis aggravates renal microvascular loss and fibrosis in swine renal artery stenosis #MMPMID26879682
  • Sun D; Eirin A; Ebrahimi B; Textor SC; Lerman A; Lerman LO
  • J Am Soc Hypertens 2016[Apr]; 10 (4): 325-35 PMID26879682show ga
  • Background: Renal function in patients with atherosclerosis and renal artery stenosis (ARAS) deteriorates more frequently than in non-atherosclerotic RAS. We hypothesized that ARAS aggravates stenotic kidney microvascular loss compared to RAS. Methods: Domestic pigs were randomized to Normal, RAS, and ARAS (RAS fed a high-cholesterol diet) groups (n=7 each). Ten weeks later stenotic kidney oxygenation, renal blood flow (RBF), and glomerular filtration rate (GFR) were evaluated in-vivo, and microvascular density by Micro-CT. Results: Blood pressure in both RAS and ARAS was elevated, and stenotic kidney RBF and GFR similarly decreased. RAS decreased the density of small-size cortical microvessels (<200 µm), while ARAS extended the decrease to medium-sized microvessels (200?300 µm). Cortical hypoxia and interstitial fibrosis increased in both RAS and ARAS, but correlated inversely with microvascular density only in RAS. Conclusions: Atherosclerosis aggravates loss of stenotic-kidney microvessels, yet additional determinants likely contribute to cortical hypoxia and fibrosis in swine ARAS.
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