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10.1016/j.jash.2016.01.019 http://scihub22266oqcxt.onion/10.1016/j.jash.2016.01.019 C4829440!4829440 !26879682     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26879682 &cmd=llinks): Failed to open stream: HTTP request failed! 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Early atherosclerosis aggravates renal microvascular loss and fibrosis in swine renal artery stenosis |pdf=|usr=}}{{26879682 }} gab.com Text Early atherosclerosis aggravates renal microvascular loss and fibrosis in swine renal artery stenosis JO: J Am Soc Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=26879682 #FOAvip Renal function in patients with atherosclerosis and renal artery stenosis (ARAS) deteriorates more frequently than in nonatherosclerotic RAS. We hypothesized that ARAS aggravates stenotic-kidney micro vascular loss compared to RAS. Domestic pigs were randomized to normal, RAS, and ARAS (RAS fed a high-cholesterol diet) groups (n = 7 each). Ten weeks later stenotic-kidney oxygenation, renal blood flow, and glomerular filtration rate (GFR) were evaluated in vivo, and micro vascular density by micro-computed tomography. Blood pressure in both RAS and ARAS was elevated; and stenotic-kidney renal blood flow and GFR similarly decreased. RAS decreased the density of small-size cortical microvessels (<200 ?m), whereas ARAS extended the decrease to medium-sized microvessels (200-300 ?m). Cortical hypoxia and interstitial fibrosis increased in both RAS and ARAS but correlated inversely with micro vascular density only in RAS. Atherosclerosis aggravates loss of stenotic-kidney microvessels, yet additional determinants likely contribute to cortical hypoxia and fibrosis in swine ARAS. Twit Text FOAVip Early atherosclerosis aggravates renal microvascular loss and fibrosis in swine renal artery stenosis ????J Am Soc Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=26879682 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26879682 #FOAvip English Wikipedia <ref>{{Cite pmid|26879682 }}</ref> Early atherosclerosis aggravates renal microvascular loss and fibrosis in swine renal artery stenosis #MMPMID26879682 Sun D ; Eirin A ; Ebrahimi B ; Textor SC ; Lerman A ; Lerman LO J Am Soc Hypertens 2016[Apr]; 10 (4 ): 325-35 PMID26879682 show ga Renal function in patients with atherosclerosis and renal artery stenosis (ARAS) deteriorates more frequently than in nonatherosclerotic RAS. We hypothesized that ARAS aggravates stenotic-kidney micro vascular loss compared to RAS. Domestic pigs were randomized to normal, RAS, and ARAS (RAS fed a high-cholesterol diet) groups (n = 7 each). Ten weeks later stenotic-kidney oxygenation, renal blood flow, and glomerular filtration rate (GFR) were evaluated in vivo, and micro vascular density by micro-computed tomography. Blood pressure in both RAS and ARAS was elevated; and stenotic-kidney renal blood flow and GFR similarly decreased. RAS decreased the density of small-size cortical microvessels (<200 ?m), whereas ARAS extended the decrease to medium-sized microvessels (200-300 ?m). Cortical hypoxia and interstitial fibrosis increased in both RAS and ARAS but correlated inversely with micro vascular density only in RAS. Atherosclerosis aggravates loss of stenotic-kidney microvessels, yet additional determinants likely contribute to cortical hypoxia and fibrosis in swine ARAS. |*Renal Circulation [MESH] |Animals [MESH] |Atherosclerosis/*complications/pathology [MESH] |Blood Pressure [MESH] |Cholesterol/blood [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Fibrosis [MESH] |Glomerular Filtration Rate [MESH] |Humans [MESH] |Hypertension, Renovascular/complications/*pathology [MESH] |Hypoxia/etiology/physiopathology [MESH] |Kidney/*blood supply/diagnostic imaging/*pathology [MESH] |Lipoproteins, LDL/blood [MESH] |Microvessels/*pathology [MESH] |Oxidative Stress [MESH] |Random Allocation [MESH] |Renal Artery Obstruction/complications/diagnostic imaging/*pathology [MESH] |Sus scrofa [MESH] |Vascular Remodeling [MESH]Early atherosclerosis aggravates renal microvascular loss and fibrosis(epmc).pdf DeepDyve Pubget Overpricing