Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27103882
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Core+Evid
2016 ; 11
(ä): 1-10
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Azilsartan medoxomil in the management of hypertension: an evidence-based review
of its place in therapy
#MMPMID27103882
Angeloni E
Core Evid
2016[]; 11
(ä): 1-10
PMID27103882
show ga
BACKGROUND: Azilsartan (AZI) is a relatively new angiotensin receptor blocker
available for the treatment of any stage of hypertension, which was eventually
given in combination with chlorthalidone (CLT). OBJECTIVE: To review pharmacology
and clinical role of AZI monotherapy and AZI/CLT or AZI/amlodipine combination
therapies for hypertension management. METHODS: PubMed, Embase, and Cochrane
Library were searched using search terms " azilsartan", "chlorthalidone,"
"pharmacology," "pharmacokinetics," "pharmacodynamics," "pharmacoeconomics," and
"cost-effectiveness." To obtain other relevant information, US Food and Drug
Association as well as manufacturer prescribing information were also reviewed.
RESULTS: Randomized controlled trials demonstrated AZI to be superior to other
sartans, such as valsartan, olmesartan, and candesartan, in terms of 24-hour
ambulatory blood pressure monitoring (ABPM) reduction with respect. That
beneficial effect of azilsartan was also associated with similar safety profiles.
When compared to other antihypertensive drugs, azilsartan was found to be
superior to any angiotensin-converting enzyme inhibitor, including ramipril, in
terms of ABPM results, and noninferior to amlodipine in terms of sleep-BP
control. The association of AZI and CLT was then found to be superior to other
sartans + thiazide combination therapies in terms of both BP lowering and goal
achievement. The combination of AZI and amlodipine has also been tested in
clinical trials, but compared only with placebo, demonstrating its superiority in
terms of efficacy and similarity in terms of safety. CONCLUSION: Azilsartan is a
safe and effective treatment option for every stage of hypertension, both alone
or in fixed-dose combination tablets with chlorthalidone or amlodipine.
Beneficial effects of AZI were also noted in patients with any degree of renal
impairment. In addition, safety profiles of AZI were similar to that of the
placebo.