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Manipulating Bacterial Communities by in situ Microbiome Engineering #MMPMID26916078
Sheth RU; Cabral V; Chen SP; Wang HH
Trends Genet 2016[Apr]; 32 (4): 189-200 PMID26916078show ga
Microbial communities inhabit our entire planet and play a crucial role in biogeochemical processes, agriculture, biotechnology, and human health. Here, we argue that ?in situ microbiome engineering? represents a new paradigm of community-scale genetic and microbial engineering. We discuss contemporary applications of this approach to directly add, remove, or modify specific sets of functions and alter community-level properties in terrestrial, aquatic, and host-associated microbial communities. Specifically, we highlight emerging in situ genome engineering approaches as tractable techniques to manipulate microbial communities with high specificity and efficacy. Finally, we describe opportunities for technological innovation and ways to bridge existing knowledge gaps to accelerate the development of in situ approaches for microbiome manipulations.