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2016 ; 2016
(ä): 9868704
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English Wikipedia
Risk Factors Associated with Irreversible Airway Obstruction in Asthma: A
Systematic Review and Meta-Analysis
#MMPMID27119087
Zhang L
; He L
; Gong J
; Liu C
Biomed Res Int
2016[]; 2016
(ä): 9868704
PMID27119087
show ga
Irreversible airway obstruction (IAO) is a subtype of asthma and relates to
poorer prognosis in some asthma patients. However, the prevalence and risk
factors for IAO are unknown. A systematic review regarding controlled clinical
studies (cohort, case-control studies) on IAO asthma in adult and/or children
affected by asthma/early wheeze was performed. Eighteen papers were identified in
this study. It was reported that the incidence of IAO at random effects or fixed
effects in severe asthma and nonsevere asthma was 0.54 (95% CI: 0.45-0.62) and
0.16 (95% CI: 0.12-0.20), respectively. In IAO asthma, the pooled odds ratio (OR)
related to smoking exposure was 2.22 (95% CI: 1.82-2.73), the OR for male,
smoking, and fractional exhaled nitric oxide (FENO) was 2.22 (95% CI: 1.82-2.7),
1.79 (95% CI: 1.46-2.19), and 2.16 (95% CI: 1.05-4.43), respectively, suggesting
these factors increase the risk of IAO. However, a decreased OR in IAO asthma was
observed due to rhinitis (OR = 0.31, 95% CI: 0.24-0.40), atopy (OR = 0.584, 95%
CI: 0.466-0.732), and atopic dermatitis (OR = 0.60, 95% CI: 0.42-0.85),
indicating these factors are associated with reduced risk of IAO. IAO in asthma
is associated with gender, smoking, FENO, rhinitis, atopy, and atopic dermatitis.