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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Opin+Cell+Biol 2016 ; 39 (ä): 84-92 Nephropedia Template TP
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The primary cilium as a cellular receiver: organizing ciliary GPCR signaling #MMPMID26926036
Hilgendorf KI; Johnson CT; Jackson PK
Curr Opin Cell Biol 2016[Apr]; 39 (ä): 84-92 PMID26926036show ga
The primary cilium is an antenna-like cellular protrusion mediating sensory and neuroendocrine signaling. Its localization within tissue architecture and a growing list of cilia-localized receptors, in particular G-protein-coupled receptors, determine a host of critical physiologies, which are disrupted in human ciliopathies. Here, we discuss recent advances in the identification and characterization of ciliary signaling components and pathways. Recent studies have highlighted the unique signaling environment of the primary cilium and we are just beginning to understand how this design allows for highly amplified and regulated signaling.