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"Soluble Tissue Factor" in the 21st Century: Definitions, Biochemistry, and
Pathophysiological Role in Thrombus Formation
#MMPMID26408917
Bogdanov VY
; Versteeg HH
Semin Thromb Hemost
2015[Oct]; 41
(7
): 700-7
PMID26408917
show ga
Tissue factor (TF), the main trigger of blood coagulation, is essential for
normal hemostasis. Over the past 20 years, heightened intravascular levels and
activity of TF have been increasingly perceived as an entity that significantly
contributes to venous as well as arterial thrombosis. Various forms of the TF
protein in the circulation have been described and proposed to be thrombogenic.
Aside from cell and vessel wall-associated TF, several forms of
non-cell-associated TF circulate in plasma and may serve as a causative factor in
thrombosis. At the present time, no firm consensus exists regarding the extent,
the vascular setting(s), and/or the mechanisms by which such TF forms contribute
to thrombus initiation and propagation. Here, we summarize the existing paradigms
and recent, sometimes paradigm-shifting findings elucidating the structural,
mechanistic, and pathophysiological characteristics of plasma-borne TF.
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