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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Comput+Biol
2016 ; 23
(4
): 239-47
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Identification of Differentially Expressed Genes in RNA-seq Data of Arabidopsis
thaliana: A Compound Distribution Approach
#MMPMID26949988
Anjum A
; Jaggi S
; Varghese E
; Lall S
; Bhowmik A
; Rai A
J Comput Biol
2016[Apr]; 23
(4
): 239-47
PMID26949988
show ga
Gene expression is the process by which information from a gene is used in the
synthesis of a functional gene product, which may be proteins. A gene is declared
differentially expressed if an observed difference or change in read counts or
expression levels between two experimental conditions is statistically
significant. To identify differentially expressed genes between two conditions,
it is important to find statistical distributional property of the data to
approximate the nature of differential genes. In the present study, the focus is
mainly to investigate the differential gene expression analysis for sequence data
based on compound distribution model. This approach was applied in RNA-seq count
data of Arabidopsis thaliana and it has been found that compound Poisson
distribution is more appropriate to capture the variability as compared with
Poisson distribution. Thus, fitting of appropriate distribution to gene
expression data provides statistically sound cutoff values for identifying
differentially expressed genes.