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10.1016/j.canlet.2015.10.005 http://scihub22266oqcxt.onion/10.1016/j.canlet.2015.10.005 C4826855!4826855!26458994     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Lett 2016 ; 380 (1): 237-42 Nephropedia Template TP {{tp|p=26458994|t=2016. Ecological paradigms to understand the dynamics of metastasis |pdf=|usr=}}{{26458994}} gab.com Text Ecological paradigms to understand the dynamics of metastasis JO: Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=26458994 #FOAvip The process by which prostate cancer cells non-randomly disseminate to the bone to form lethal metastases remains unknown. Metastasis is the ultimate consequence of the long-range dispersal of a cancer cell from the primary tumor to a distant secondary site. In order to metastasize, the actively emigrating cell must move. Movement ecology describes an individual?s migration between habitats without the requirement of conscious decision-making. Specifically, this paradigm describes four interacting components that influence the dynamic process of metastasis: (1) the microenvironmental pressures exerted on the cancer cell, (2) how the individual cell reacts to these external pressures, (3) the phenotypic switch of a cell to gain the physical traits required for movement, and (4) the ability of the cancer cell to navigate to a specific site. A deeper understanding of each of these components will lead to the development of novel therapeutics targeted to interrupt previously unidentified steps of metastasis. Twit Text FOAVip Ecological paradigms to understand the dynamics of metastasis ????Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=26458994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26458994 #FOAvip English Wikipedia <ref>{{Cite pmid|26458994}}</ref> Ecological paradigms to understand the dynamics of metastasis #MMPMID26458994 Amend SR; Sounak Roy; Brown JS; Pienta KJ Cancer Lett 2016[Sep]; 380 (1): 237-42 PMID26458994show ga The process by which prostate cancer cells non-randomly disseminate to the bone to form lethal metastases remains unknown. Metastasis is the ultimate consequence of the long-range dispersal of a cancer cell from the primary tumor to a distant secondary site. In order to metastasize, the actively emigrating cell must move. Movement ecology describes an individual?s migration between habitats without the requirement of conscious decision-making. Specifically, this paradigm describes four interacting components that influence the dynamic process of metastasis: (1) the microenvironmental pressures exerted on the cancer cell, (2) how the individual cell reacts to these external pressures, (3) the phenotypic switch of a cell to gain the physical traits required for movement, and (4) the ability of the cancer cell to navigate to a specific site. A deeper understanding of each of these components will lead to the development of novel therapeutics targeted to interrupt previously unidentified steps of metastasis. äEcological paradigms to understand the dynamics of metastasis (epmc).pdf DeepDyve Pubget Overpricing