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10.1016/j.cell.2016.03.015 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.03.015 C4826477!4826477!27058663     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27058663&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 165 (2): 303-16 Nephropedia Template TP {{tp|p=27058663|t=2016. Core circadian clock genes regulate leukemia stem cells in AML |pdf=|usr=}}{{27058663}} gab.com Text Core circadian clock genes regulate leukemia stem cells in AML JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27058663 #FOAvip Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon serial transplantation in animal models, and elimination of this cell population is required for curative therapies. Here, we describe a series of pooled, in vivo RNA interference (RNAi) screens to identify essential transcription factors (TFs) in a murine model of acute myeloid leukemia (AML) with genetically- and phenotypically-defined LSCs. These screens reveal the heterodimeric, circadian rhythm TFs Clock and Bmal1 as genes required for the growth of AML cells in vitro and in vivo. Disruption of canonical circadian pathway components produces anti-leukemic effects, including impaired proliferation, enhanced myeloid differentiation, and depletion of LSCs. We find that both normal and malignant hematopoietic cells harbor an intact clock with robust circadian oscillations, and genetic knockout models reveal a leukemia-specific dependence on the pathway. Our findings establish a role for the core circadian clock genes in AML. Twit Text FOAVip Core circadian clock genes regulate leukemia stem cells in AML ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27058663 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27058663 #FOAvip English Wikipedia <ref>{{Cite pmid|27058663}}</ref> Core circadian clock genes regulate leukemia stem cells in AML #MMPMID27058663 Puram RV; Kowalczyk MS; de Boer CG; Schneider RK; Miller PG; McConkey M; Tothova Z; Tejero H; Heckl D; Järås M; Chen MC; Li H; Tamayo A; Cowley GS; Rozenblatt-Rosen O; Al-Shahrour F; Regev A; Ebert BL Cell 2016[Apr]; 165 (2): 303-16 PMID27058663show ga Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon serial transplantation in animal models, and elimination of this cell population is required for curative therapies. Here, we describe a series of pooled, in vivo RNA interference (RNAi) screens to identify essential transcription factors (TFs) in a murine model of acute myeloid leukemia (AML) with genetically- and phenotypically-defined LSCs. These screens reveal the heterodimeric, circadian rhythm TFs Clock and Bmal1 as genes required for the growth of AML cells in vitro and in vivo. Disruption of canonical circadian pathway components produces anti-leukemic effects, including impaired proliferation, enhanced myeloid differentiation, and depletion of LSCs. We find that both normal and malignant hematopoietic cells harbor an intact clock with robust circadian oscillations, and genetic knockout models reveal a leukemia-specific dependence on the pathway. Our findings establish a role for the core circadian clock genes in AML. äCore circadian clock genes regulate leukemia stem cells in AML (epmc).pdf DeepDyve Pubget Overpricing