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2016 ; 100
(7
): 1405-14
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The Use of Genomics and Pathway Analysis in Our Understanding and Prediction of
Clinical Renal Transplant Injury
#MMPMID26447506
Menon MC
; Keung KL
; Murphy B
; O?Connell PJ
Transplantation
2016[Jul]; 100
(7
): 1405-14
PMID26447506
show ga
The development and application of high-throughput molecular profiling have
transformed the study of human diseases. The problem of handling large, complex
data sets has been facilitated by advances in complex computational analysis. In
this review, the recent literature regarding the application of transcriptional
genomic information to renal transplantation, with specific reference to acute
rejection, acute kidney injury in allografts, chronic allograft injury, and
tolerance is discussed, as is the current published data regarding other "omics"
strategies-proteomics, metabolomics, and the microRNA transcriptome. These data
have shed new light on our understanding of the pathogenesis of specific disease
conditions after renal transplantation, but their utility as a biomarker of
disease has been hampered by study design and sample size. This review aims to
highlight the opportunities and obstacles that exist with genomics and other
related technologies to better understand and predict renal allograft outcome.