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10.1016/j.cell.2016.02.023 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.02.023 C4826308!4826308!26997483     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 165 (2): 343-56 Nephropedia Template TP {{tp|p=26997483|t=2016. The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia |pdf=|usr=}}{{26997483}} gab.com Text The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26997483 #FOAvip Control of plasma glucose level is essential to organismal survival. Sustained inflammation has been implicated in control of glucose homeostasis in cases of infection, obesity, and type 2 diabetes; however, the precise role of inflammation in these complex disease states remains poorly understood. Here, we find that sustained inflammation results in elevated plasma glucose due to increased hepatic glucose production. We find that sustained inflammation suppresses CYP7A1, leading to accumulation of intermediate metabolites at the branch point of the mevalonate pathway. This results in prenylation of RHOC, which is concomitantly induced by inflammatory cytokines. Subsequent activation of RHO-associated protein kinase results in elevated plasma glucose. These findings uncover an unexpected mechanism by which sustained inflammation alters glucose homeostasis. Twit Text FOAVip The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26997483 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26997483 #FOAvip English Wikipedia <ref>{{Cite pmid|26997483}}</ref> The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia #MMPMID26997483 Okin D; Medzhitov R Cell 2016[Apr]; 165 (2): 343-56 PMID26997483show ga Control of plasma glucose level is essential to organismal survival. Sustained inflammation has been implicated in control of glucose homeostasis in cases of infection, obesity, and type 2 diabetes; however, the precise role of inflammation in these complex disease states remains poorly understood. Here, we find that sustained inflammation results in elevated plasma glucose due to increased hepatic glucose production. We find that sustained inflammation suppresses CYP7A1, leading to accumulation of intermediate metabolites at the branch point of the mevalonate pathway. This results in prenylation of RHOC, which is concomitantly induced by inflammatory cytokines. Subsequent activation of RHO-associated protein kinase results in elevated plasma glucose. These findings uncover an unexpected mechanism by which sustained inflammation alters glucose homeostasis. äThe Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Res(epmc).pdf DeepDyve Pubget Overpricing