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10.1016/j.stem.2016.03.001 http://scihub22266oqcxt.onion/10.1016/j.stem.2016.03.001 C4826298!4826298!27044474     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Stem+Cell 2016 ; 18 (4): 456-66 Nephropedia Template TP {{tp|p=27044474|t=2016. Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration |pdf=|usr=}}{{27044474}} gab.com Text Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=27044474 #FOAvip Mammals have partially lost the extensive regenerative capabilities of some vertebrates, possibly as a result of chromatin-remodeling mechanisms that enforce terminal differentiation. Here, we show that deleting the SWI/SNF component Arid1a substantially improves mammalian regeneration. Arid1a expression is suppressed in regenerating tissues, and genetic deletion of Arid1a increases tissue repair following an array of injuries. Arid1a deficiency in the liver increases proliferation, reduces tissue damage and fibrosis, and improves organ function following surgical resection and chemical injuries. Hepatocyte-specific deletion is also sufficient to increase proliferation and regeneration without excessive overgrowth, and global Arid1a disruption potentiates soft tissue healing in the ear. We show Arid1a loss reprograms chromatin to restrict promoter access by transcription factors such as C/ebp?, which enforces differentiation, and E2F4, which suppresses cell cycle reentry. Thus, epigenetic reprogramming mediated by deletion of a single gene improves mammalian regeneration and suggests strategies to promote tissue repair after injury. Twit Text FOAVip Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=27044474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27044474 #FOAvip English Wikipedia <ref>{{Cite pmid|27044474}}</ref> Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration #MMPMID27044474 Sun X; Chuang JC; Kanchwala M; Wu L; Celen C; Li L; Liang H; Zhang S; Maples T; Nguyen LH; Wang SC; Signer RAJ; Sorouri M; Nassour I; Liu X; Xu J; Wu M; Zhao Y; Kuo YC; Wang Z; Xing C; Zhu H Cell Stem Cell 2016[Apr]; 18 (4): 456-66 PMID27044474show ga Mammals have partially lost the extensive regenerative capabilities of some vertebrates, possibly as a result of chromatin-remodeling mechanisms that enforce terminal differentiation. Here, we show that deleting the SWI/SNF component Arid1a substantially improves mammalian regeneration. Arid1a expression is suppressed in regenerating tissues, and genetic deletion of Arid1a increases tissue repair following an array of injuries. Arid1a deficiency in the liver increases proliferation, reduces tissue damage and fibrosis, and improves organ function following surgical resection and chemical injuries. Hepatocyte-specific deletion is also sufficient to increase proliferation and regeneration without excessive overgrowth, and global Arid1a disruption potentiates soft tissue healing in the ear. We show Arid1a loss reprograms chromatin to restrict promoter access by transcription factors such as C/ebp?, which enforces differentiation, and E2F4, which suppresses cell cycle reentry. Thus, epigenetic reprogramming mediated by deletion of a single gene improves mammalian regeneration and suggests strategies to promote tissue repair after injury. äSuppression of the SWI/SNF component Arid1a promotes mammalian regener(epmc).pdf DeepDyve Pubget Overpricing