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10.18632/oncotarget.6777

http://scihub22266oqcxt.onion/10.18632/oncotarget.6777
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C4826212!4826212!26735890
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suck abstract from ncbi


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pmid26735890      Oncotarget 2016 ; 7 (4): 4379-84
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  • Effect of pravastatin on the survival of patients with advanced gastric cancer #MMPMID26735890
  • Bujanda L; Rodríguez-González A; Sarasqueta C; Eizaguirre E; Hijona E; Marín JJ; Perugorria MJ; Banales JM; Cosme A
  • Oncotarget 2016[Jan]; 7 (4): 4379-84 PMID26735890show ga
  • Objectives: A fluoropyrimidine plus cisplatin combined with surgery is standard first-line treatment for advanced gastric cancer. We evaluated the effect of pravastatin on overall survival in patients with advanced gastric cancer in a prospective cohort study. Methods: At the time of surgery, we assigned 60 patients with advanced gastric cancer (stage III or IV) to receive standard first-line treatment (control group) or standard first-line treatment plus pravastatin at a dose of 40 mg once daily (pravastatin group). The minimum follow-up period was 4 years and the maximum of 6 years. Results: The mean of age was 66 years and the TNM stage was III and IV in 65% and 35% of patients, respectively. There was no significant difference between the two groups (control vs pravastatin) in median overall survival (15 vs 14 months; P = 0.8). Predictors of survival were the stage (hazard ratio of death stage IV (III stage as reference): 4.4; 95% CI: 2?9.7; p < 0.05) and older age (hazard ratio of death ? 65 years (< 65 years as reference): 2.8; 95% CI: 1.3?6; p < 0.05). Conclusions: Pravastatin did not improve outcome in patients with advanced gastric cancer.
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