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10.18632/oncotarget.6483 http://scihub22266oqcxt.onion/10.18632/oncotarget.6483 C4826203!4826203 !26646322     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26646322 &cmd=llinks): Failed to open stream: HTTP request failed! 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Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF-? signaling in nasopharyngeal carcinoma |pdf=|usr=}}{{26646322 }} gab.com Text Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF- signaling in nasopharyngeal carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26646322 #FOAvip Metastasis is the main cause of cancer-related deaths. Nasopharyngeal carcinoma (NPC) is characterized by severe local invasion and high incidence of regional lymph node metastasis, which represents poor prognosis. However, the underlying mechanism that induces lymph node metastasis of NPC remains largely unknown. Herein, we report that flotillin-1 (FLOT1), a component of lipid raft, which was reported to be involved in tumor progression, was robustly upregulated in the NPC samples with lymph node metastasis. High FLOT1 expression was significantly associated with N classification as well as poorer overall and disease-free survivals in 169 archived clinical NPC samples. Overexpression of FLOT1 enhanced the migratory and invasive abilities of NPC cells in vitro, and more importantly, promoted invasion into the surrounding tissues and metastasis to lymph nodes in vivo. Whereas silencing of endogenous FLOT1 in NPC cells decreased the local invasion and metastasis to lymph nodes. Furthermore, FLOT1 induced the expression and secretion of TGF-?1, facilitated the activation of TGF-?/Smad3 signaling to effectuate epithelial-mesenchymal transition. Our findings present new evidence that FLOT1 plays an important role in promoting aggressive behavior of NPC and provide new insights into the regulatory mechanism of TGF-? signaling. Twit Text FOAVip Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF- signaling in nasopharyngeal carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26646322 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26646322 #FOAvip English Wikipedia <ref>{{Cite pmid|26646322 }}</ref> Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF-? signaling in nasopharyngeal carcinoma #MMPMID26646322 Cao S ; Cui Y ; Xiao H ; Mai M ; Wang C ; Xie S ; Yang J ; Wu S ; Li J ; Song L ; Guo X ; Lin C Oncotarget 2016[Jan]; 7 (4 ): 4252-64 PMID26646322 show ga Metastasis is the main cause of cancer-related deaths. Nasopharyngeal carcinoma (NPC) is characterized by severe local invasion and high incidence of regional lymph node metastasis, which represents poor prognosis. However, the underlying mechanism that induces lymph node metastasis of NPC remains largely unknown. Herein, we report that flotillin-1 (FLOT1), a component of lipid raft, which was reported to be involved in tumor progression, was robustly upregulated in the NPC samples with lymph node metastasis. High FLOT1 expression was significantly associated with N classification as well as poorer overall and disease-free survivals in 169 archived clinical NPC samples. Overexpression of FLOT1 enhanced the migratory and invasive abilities of NPC cells in vitro, and more importantly, promoted invasion into the surrounding tissues and metastasis to lymph nodes in vivo. Whereas silencing of endogenous FLOT1 in NPC cells decreased the local invasion and metastasis to lymph nodes. Furthermore, FLOT1 induced the expression and secretion of TGF-?1, facilitated the activation of TGF-?/Smad3 signaling to effectuate epithelial-mesenchymal transition. Our findings present new evidence that FLOT1 plays an important role in promoting aggressive behavior of NPC and provide new insights into the regulatory mechanism of TGF-? signaling. |*Cell Movement [MESH] |Animals [MESH] |Apoptosis [MESH] |Blotting, Western [MESH] |Carcinoma [MESH] |Cell Proliferation [MESH] |Epithelial-Mesenchymal Transition [MESH] |Humans [MESH] |Immunoenzyme Techniques [MESH] |Lymphatic Metastasis [MESH] |Membrane Proteins/*metabolism [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Nasopharyngeal Carcinoma [MESH] |Nasopharyngeal Neoplasms/metabolism/*pathology [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Staging [MESH] |Prognosis [MESH] |Signal Transduction [MESH] |Transforming Growth Factor beta/*metabolism [MESH] |Tumor Cells, Cultured [MESH]Upregulation of flotillin-1 promotes invasion and metastasis by activa(epmc).pdf DeepDyve Pubget Overpricing