Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.18632/oncotarget.6702 http://scihub22266oqcxt.onion/10.18632/oncotarget.6702 C4826194!4826194!26716641     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (4): 4122-41 Nephropedia Template TP {{tp|p=26716641|t=2016. Autophagy is involved in TGF-?1-induced protective mechanisms and formation of cancer-associated fibroblasts phenotype in tumor microenvironment |pdf=|usr=}}{{26716641}} gab.com Text Autophagy is involved in TGF- 1-induced protective mechanisms and formation of cancer-associated fibroblasts phenotype in tumor microenvironment JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26716641 #FOAvip Transforming growth factor-?1 (TGF-?1) present in tumor microenvironment acts in a coordinated fashion to either suppress or promote tumor development. However, the molecular mechanisms underlying the effects of TGF-?1 on tumor microenvironment are not well understood. Our clinical data showed a positive association between TGF-?1 expression and cancer-associated fibroblasts (CAFs) in tumor microenvironment of breast cancer patients. Thus we employed starved NIH3T3 fibroblasts in vitro and 4T1 cells mixed with NIH3T3 fibroblasts xenograft model in vivo to simulate nutritional deprivation of tumor microenvironment to explore the effects of TGF-?1. We demonstrated that TGF-?1 protected NIH3T3 fibroblasts from Star-induced growth inhibition, mitochondrial damage and cell apoptosis. Interestingly, TGF-?1 induced the formation of CAFs phenotype in starvation (Star)-treated NIH3T3 fibroblasts and xenografted Balb/c mice, which promoted breast cancer tumor growth. In both models, autophagy agonist rapamycin increased TGF-?1-induced protective effects and formation of CAFs phenotypes, while autophagy inhibitor 3-methyladenine, Atg5 knockdown or TGF-? type I receptor kinase inhibitor LY-2157299 blocked TGF-?1 induced these effects. Taken together, our results indicated that TGF-?/Smad autophagy was involved in TGF-?1-induced protective effects and formation of CAFs phenotype in tumor microenvironment, which may be used as therapy targets in breast cancer. Twit Text FOAVip Autophagy is involved in TGF- 1-induced protective mechanisms and formation of cancer-associated fibroblasts phenotype in tumor microenvironment ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26716641 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26716641 #FOAvip English Wikipedia <ref>{{Cite pmid|26716641}}</ref> Autophagy is involved in TGF-?1-induced protective mechanisms and formation of cancer-associated fibroblasts phenotype in tumor microenvironment #MMPMID26716641 Liu FL; Mo EP; Yang L; Du J; Wang HS; Zhang H; Kurihara H; Xu J; Cai SH Oncotarget 2016[Jan]; 7 (4): 4122-41 PMID26716641show ga Transforming growth factor-?1 (TGF-?1) present in tumor microenvironment acts in a coordinated fashion to either suppress or promote tumor development. However, the molecular mechanisms underlying the effects of TGF-?1 on tumor microenvironment are not well understood. Our clinical data showed a positive association between TGF-?1 expression and cancer-associated fibroblasts (CAFs) in tumor microenvironment of breast cancer patients. Thus we employed starved NIH3T3 fibroblasts in vitro and 4T1 cells mixed with NIH3T3 fibroblasts xenograft model in vivo to simulate nutritional deprivation of tumor microenvironment to explore the effects of TGF-?1. We demonstrated that TGF-?1 protected NIH3T3 fibroblasts from Star-induced growth inhibition, mitochondrial damage and cell apoptosis. Interestingly, TGF-?1 induced the formation of CAFs phenotype in starvation (Star)-treated NIH3T3 fibroblasts and xenografted Balb/c mice, which promoted breast cancer tumor growth. In both models, autophagy agonist rapamycin increased TGF-?1-induced protective effects and formation of CAFs phenotypes, while autophagy inhibitor 3-methyladenine, Atg5 knockdown or TGF-? type I receptor kinase inhibitor LY-2157299 blocked TGF-?1 induced these effects. Taken together, our results indicated that TGF-?/Smad autophagy was involved in TGF-?1-induced protective effects and formation of CAFs phenotype in tumor microenvironment, which may be used as therapy targets in breast cancer. äAutophagy is involved in TGF-?1-induced protective mechanisms and form(epmc).pdf DeepDyve Pubget Overpricing