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10.18632/oncotarget.6756 http://scihub22266oqcxt.onion/10.18632/oncotarget.6756 C4826169!4826169!26716902     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (4): 3777-90 Nephropedia Template TP {{tp|p=26716902|t=2016. Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction |pdf=|usr=}}{{26716902}} gab.com Text Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26716902 #FOAvip Leukemia inhibitory factor (LIF) is a multi-function cytokine. Its role in cancer is not well-understood. Recent studies including ours show that LIF is frequently overexpressed in many types of human tumors and promotes the progression and metastasis of tumors. However, the underlying mechanism of LIF's promoting effects on tumor progression and metastasis is poorly defined. Epithelial-mesenchymal transition (EMT) plays an important role in tumor metastasis. This study reports that LIF promotes EMT in human tumor cells. Overexpression of LIF promotes tumor cells to acquire mesenchymal features, including morphological changes of cells from epithelial-like to mesenchymal-like, increased expression levels of mesenchymal markers and decreased expression of epithelial markers. Knockdown of endogenous LIF reverses EMT in cancer cells. We further identified that LIF induces the expression of microRNA-21 (miR-21), which in turn mediates the promoting effect of LIF on EMT. LIF induces miR-21 expression through the activation of STAT3. Importantly, blocking miR-21 function greatly abolished the promoting effect of LIF on EMT and the migration ability of cancer cells. Taken together, results from this study identified an important function and a novel underlying mechanism of LIF in EMT and tumor metastasis. Twit Text FOAVip Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26716902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26716902 #FOAvip English Wikipedia <ref>{{Cite pmid|26716902}}</ref> Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction #MMPMID26716902 Yue X; Zhao Y; Zhang C; Li J; Liu Z; Liu J; Hu W Oncotarget 2016[Jan]; 7 (4): 3777-90 PMID26716902show ga Leukemia inhibitory factor (LIF) is a multi-function cytokine. Its role in cancer is not well-understood. Recent studies including ours show that LIF is frequently overexpressed in many types of human tumors and promotes the progression and metastasis of tumors. However, the underlying mechanism of LIF's promoting effects on tumor progression and metastasis is poorly defined. Epithelial-mesenchymal transition (EMT) plays an important role in tumor metastasis. This study reports that LIF promotes EMT in human tumor cells. Overexpression of LIF promotes tumor cells to acquire mesenchymal features, including morphological changes of cells from epithelial-like to mesenchymal-like, increased expression levels of mesenchymal markers and decreased expression of epithelial markers. Knockdown of endogenous LIF reverses EMT in cancer cells. We further identified that LIF induces the expression of microRNA-21 (miR-21), which in turn mediates the promoting effect of LIF on EMT. LIF induces miR-21 expression through the activation of STAT3. Importantly, blocking miR-21 function greatly abolished the promoting effect of LIF on EMT and the migration ability of cancer cells. Taken together, results from this study identified an important function and a novel underlying mechanism of LIF in EMT and tumor metastasis. äLeukemia inhibitory factor promotes EMT through STAT3-dependent miR-21(epmc).pdf DeepDyve Pubget Overpricing