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2016 ; 10
(2
): 261-77
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Prevention of non-enzymatic glycosylation (glycation): Implication in the
treatment of diabetic complication
#MMPMID27103908
Younus H
; Anwar S
Int J Health Sci (Qassim)
2016[Apr]; 10
(2
): 261-77
PMID27103908
show ga
Non-enzymatic glycosylation (glycation) plays an important role in the
development of physiological and pathophysiological processes such as aging,
diabetes, atherosclerosis, neurodegenerative diseases and chronic renal failure.
Preventing glycation can minimize diabetic complications. Glycation can be
prevented by the natural defence system in the body, synthetic inhibitors and
natural inhibitors. Synthetic inhibitors may prevent glycation through several
possible mechanisms. They might inhibit the glycation by interfering with the
attachment of sugars with proteins, by inhibiting the late stage of glycation or
by preventing Amadori product formation. Furthermore, their ability to scavenge
free radicals and to break cross-links might be other mechanisms responsible for
their potential to inhibit glycation. Naturally occurring phytochemicals/products
have been found to be relatively non-toxic as compared to synthetic compounds,
and are inexpensive and available in an ingestible form. A large number of plants
and natural biomolecules have been shown to have antidiabetic effects. Several
hypoglycaemic compounds have anti-oxidant properties. The present review
describes the various ways in which glycation can be prevented.