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2016 ; 10
(2
): 249-57
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Efficiency of the occlusion therapy with and without levodopa-carbidopa in
amblyopic children-A tertiary care centre experience
#MMPMID27103907
Sofi IA
; Gupta SK
; Bharti A
; Tantry TG
Int J Health Sci (Qassim)
2016[Apr]; 10
(2
): 249-57
PMID27103907
show ga
OBJECTIVES: To assess the role, efficacy and tolerability of levodopa-carbidopa
in the management of small and older children with different types of amblyopia.
METHODOLOGY: Prospective randomised placebo controlled clinical study, in which
50 amblyopic patients between 5 and 20 years of age with visual acuity (V/A) <
20/40 were included, was carried on. After having attained the best possible
refractive correction, patients were randomly divided into 2 groups. They were
prescribed levodopa-carbidopa (10:1) (4-6mg/kg/day in 2-3 divided doses) or
placebo, plus full-time occlusion of the sound eye, for a period of three months.
Assessment of improvement in V/A, compliance and tolerance was done at follow up
visits. Data was analyzed using computer software Ms-Excel and Epi-Info Version
6.0. The statistical significance was assessed by Chi-Square/Fisher's Exact Test.
RESULTS: Visual acuity for the amblyopic eye improved significantly in both
groups but there was significant improvement in group 1 than group 2 (P =
0.0001). In a subgroup of patients older than 12 years, levodopa group showed
statistically significant improvement in baseline V/A (P = 0.0001). In patients
with severe amblyopia, each group showed significant improvement in baseline V/A
(p < 0.05), but was significantly more in group 1 (P = 0.0001). Compliance rates
were similar among the groups and levodopa-carbidopa at a dose range of 4-6
mg/kg/day was well tolerated. CONCLUSION: Levodopa-carbidopa can be used as an
adjunct to conventional occlusion therapy in amblyopia particularly in older
children and severe cases of amblyopia, and it is well tolerated.