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Effects of sodium methyldithiocarbamate on selected parameters of innate immunity
and clearance of bacteria in a mouse model of sepsis
#MMPMID26281915
Tan W
; Pruett SB
Life Sci
2015[Oct]; 139
(?): 1-7
PMID26281915
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AIMS: Sodium methyldithiocarbamate (SMD), the third most widely used conventional
pesticide in the United States, has been reported to inhibit several parameters
associated with inflammation and to decrease resistance to infection. In a
previous study, survival time was markedly decreased when mice were treated
orally with SMD shortly before challenge with a high dose of Escherichia coli (E.
coli) that was lethal to most of the control mice. In the present study, we
evaluated selected parameters of the innate immune system using a lower challenge
dose of E. coli, to determine which (if any) of these parameters reflected
continued changes through 24h. MAIN METHODS: Bacterial clearance from the
peritoneal cavity, production of chemokines and cytokines, and body temperature
were measured. KEY FINDINGS: All these parameters were reduced by SMD up to 12h
after bacterial challenge, but the concentration of the anti-inflammatory
cytokine IL-10 was increased. Even so, mice in the control and SMD-treated groups
cleared most bacteria by 24h. Other parameters (cytokine concentrations and body
temperature) were also normal or near normal by 24h. The same dosage of SMD
administered intranasally also did not significantly decrease survival.
Hypothermia from 16 to 28 h correlated with lethal outcome, but SMD significantly
increased hypothermia only at 2 and 4h after challenge. SIGNIFICANCE: In spite of
substantial early inhibition by SMD of parameters known to be important for
resistance to infection, bacterial clearance and survival were not altered,
suggesting immunological reserve and/or rapid recovery after transient effects of
SMD.
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