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10.1080/15384101.2015.1093710 http://scihub22266oqcxt.onion/10.1080/15384101.2015.1093710 C4825625!4825625!26566869     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26566869&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2015 ; 14 (21): 3506-12 Nephropedia Template TP {{tp|p=26566869|t=2015. The oncolytic peptide LTX-315 triggers necrotic cell death |pdf=|usr=}}{{26566869}} gab.com Text The oncolytic peptide LTX-315 triggers necrotic cell death JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=26566869 #FOAvip The oncolytic peptide LTX-315 has been designed for killing human cancer cells and turned out to stimulate anti-cancer immune responses when locally injected into tumors established in immunocompetent mice. Here, we investigated the question whether LTX-315 induces apoptosis or necrosis. Transmission electron microscopy or morphometric analysis of chromatin-stained tumor cells revealed that LTX-315 failed to induce apoptotic nuclear condensation and rather induced a necrotic phenotype. Accordingly, LTX-315 failed to stimulate the activation of caspase-3, and inhibition of caspases by means of Z-VAD-fmk was unable to reduce cell killing by LTX-315. In addition, 2 prominent inhibitors of regulated necrosis (necroptosis), namely, necrostatin-1 and cycosporin A, failed to reduce LTX-315-induced cell death. In conclusion, it appears that LTX-315 triggers unregulated necrosis, which may contribute to its pro-inflammatory and pro-immune effects. Twit Text FOAVip The oncolytic peptide LTX-315 triggers necrotic cell death ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=26566869 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26566869 #FOAvip English Wikipedia <ref>{{Cite pmid|26566869}}</ref> The oncolytic peptide LTX-315 triggers necrotic cell death #MMPMID26566869 Forveille S; Zhou H; Sauvat A; Bezu L; Müller K; Liu P; Zitvogel L; Pierron G; Rekdal Ø; Kepp O; Kroemer G Cell Cycle 2015[]; 14 (21): 3506-12 PMID26566869show ga The oncolytic peptide LTX-315 has been designed for killing human cancer cells and turned out to stimulate anti-cancer immune responses when locally injected into tumors established in immunocompetent mice. Here, we investigated the question whether LTX-315 induces apoptosis or necrosis. Transmission electron microscopy or morphometric analysis of chromatin-stained tumor cells revealed that LTX-315 failed to induce apoptotic nuclear condensation and rather induced a necrotic phenotype. Accordingly, LTX-315 failed to stimulate the activation of caspase-3, and inhibition of caspases by means of Z-VAD-fmk was unable to reduce cell killing by LTX-315. In addition, 2 prominent inhibitors of regulated necrosis (necroptosis), namely, necrostatin-1 and cycosporin A, failed to reduce LTX-315-induced cell death. In conclusion, it appears that LTX-315 triggers unregulated necrosis, which may contribute to its pro-inflammatory and pro-immune effects. äThe oncolytic peptide LTX-315 triggers necrotic cell death (epmc).pdf DeepDyve Pubget Overpricing