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10.6061/clinics/2016(04)05 http://scihub22266oqcxt.onion/10.6061/clinics/2016(04)05 C4825195!4825195!27166770     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27166770&cmd=llinks): Failed to open stream: HTTP request failed! 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Clinical presentation of hemophagocytic lymphohistiocytosis in adults is less typical than in children |pdf=|usr=}}{{27166770}} gab.com Text Clinical presentation of hemophagocytic lymphohistiocytosis in adults is less typical than in children JO: Clinics (Sao Paulo) http://www.kidney.de/pget.php?&tw=1&pmid=27166770 #FOAvip OBJECTIVE:: Hemophagocytic lymphohistiocytosis in adults is largely underdiagnosed. To improve the rate and accuracy of diagnosis in adults, the clinical and laboratory characteristics of hemophagocytic lymphohistiocytosis were analyzed in and compared between adults and children in a Chinese cohort. METHOD:: Data from 50 hemophagocytic lymphohistiocytosis patients, including 34 adults and 16 children who fulfilled the 2004 hemophagocytic lymphohistiocytosis diagnostic criteria, were collected and analyzed. RESULTS:: 1. Etiological factors: The proportion of Epstein-Barr virus infection was lower in adults compared with children, whereas fungal infection and natural killer/T cell lymphoma were more frequent in adults (P<0.05). 2. Clinical manifestations and laboratory findings: Over 90% of adults and pediatric patients presented with fever, thrombocytopenia and high serum ferritin levels. However, in adults, the proportions of hepatomegaly, splenomegaly and jaundice were much lower (P<0.01) than in children, and serous cavity effusion was more frequent in adult patients (P<0.05). More children had hemoglobin <90 g/L, total bilirubin >19 mmol/L and lactate dehydrogenase >500 U/L compared with adults (P<0.05). 3. The time interval from the onset of symptoms to clinical diagnosis was significantly shorter in pediatric patients than in adults (P<0.05). CONCLUSIONS:: Certain clinical features were different between the two groups. The less characteristic clinical presentation of hemophagocytic lymphohistiocytosis in adults may make the disease more difficult to diagnose. Our findings suggest that hemophagocytic lymphohistiocytosis should be considered when an adult patient presents with the above-mentioned symptoms. Twit Text FOAVip Clinical presentation of hemophagocytic lymphohistiocytosis in adults is less typical than in children ????Clinics (Sao Paulo) http://www.kidney.de/pget.php?&tw=1&pmid=27166770 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27166770 #FOAvip English Wikipedia <ref>{{Cite pmid|27166770}}</ref> Clinical presentation of hemophagocytic lymphohistiocytosis in adults is less typical than in children #MMPMID27166770 Zhang Z; Wang J; Ji B; von Bahr Greenwood T; Zhang Y; Wang Y; Kong D; Li A; Jiang Y; Guo Y; Liu X; Wang Y; Dou A; Li N; Henter JI; Sun G; Zheng C Clinics (Sao Paulo) 2016[Apr]; 71 (4): 205-9 PMID27166770show ga OBJECTIVE:: Hemophagocytic lymphohistiocytosis in adults is largely underdiagnosed. To improve the rate and accuracy of diagnosis in adults, the clinical and laboratory characteristics of hemophagocytic lymphohistiocytosis were analyzed in and compared between adults and children in a Chinese cohort. METHOD:: Data from 50 hemophagocytic lymphohistiocytosis patients, including 34 adults and 16 children who fulfilled the 2004 hemophagocytic lymphohistiocytosis diagnostic criteria, were collected and analyzed. RESULTS:: 1. Etiological factors: The proportion of Epstein-Barr virus infection was lower in adults compared with children, whereas fungal infection and natural killer/T cell lymphoma were more frequent in adults (P<0.05). 2. Clinical manifestations and laboratory findings: Over 90% of adults and pediatric patients presented with fever, thrombocytopenia and high serum ferritin levels. However, in adults, the proportions of hepatomegaly, splenomegaly and jaundice were much lower (P<0.01) than in children, and serous cavity effusion was more frequent in adult patients (P<0.05). More children had hemoglobin <90 g/L, total bilirubin >19 mmol/L and lactate dehydrogenase >500 U/L compared with adults (P<0.05). 3. The time interval from the onset of symptoms to clinical diagnosis was significantly shorter in pediatric patients than in adults (P<0.05). CONCLUSIONS:: Certain clinical features were different between the two groups. The less characteristic clinical presentation of hemophagocytic lymphohistiocytosis in adults may make the disease more difficult to diagnose. Our findings suggest that hemophagocytic lymphohistiocytosis should be considered when an adult patient presents with the above-mentioned symptoms. äClinical presentation of hemophagocytic lymphohistiocytosis in adults (epmc).pdf DeepDyve Pubget Overpricing