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2016 ; 7
(ä): 480
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Are Plasma Oxytocin and Vasopressin Levels Reflective of Amygdala Activation
during the Processing of Negative Emotions? A Preliminary Study
#MMPMID27092094
Motoki K
; Sugiura M
; Takeuchi H
; Kotozaki Y
; Nakagawa S
; Yokoyama R
; Kawashima R
Front Psychol
2016[]; 7
(ä): 480
PMID27092094
show ga
Plasma oxytocin (OT) and arginine vasopressin (AVP) are associated with
individual differences in emotional responses and behaviors. The amygdala is
considered to be an important brain region for regulating emotion-based behavior,
with OT and AVP modulating activity in the amygdala during the processing of
negative emotions. In particular, increased OT levels may diminish amygdala
activation (anxiolytic effects) and enhanced AVP levels may augment amygdala
activation (anxiogenic effects) when negative emotions are processed. A growing
body of research has shown that the effects of OT and AVP are modulated by sex:
the aforementioned anxiolytic effects of OT and the anxiogenic effects of AVP
occur in men, but not in women. However, we have little knowledge regarding the
biological mechanisms underlying OT and AVP plasma levels or their respective
anxiogenic and anxiolytic effects; similarly, little is known about the causes
and nature of sex differences related to these neuropeptides and their effects on
emotional processing. In the current study, we focused on the neural functions
associated with the biological mechanisms underlying such effects. We
hypothesized that amygdala activation would correlate with trait plasma OT
(anxiolytic effects) and AVP (anxiogenic effects) levels because the amygdala is
thought to affect the coordinated release of these neuropeptides following
affective experiences. We further hypothesized that the effects would be
modulated by sex. We assessed 51 participants (male and female) using a paradigm
involving negative emotion in conjunction with functional magnetic resonance
imaging and measurements of plasma OT and AVP levels. We determined that
increased plasma AVP levels were positively associated with amygdala activation
(anxiogenic effects) in men, but not in women. These findings highlight the
potential underlying neural mechanisms of plasma AVP levels in men.