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Legionella pneumophila: The Paradox of a Highly Sensitive Opportunistic
Waterborne Pathogen Able to Persist in the Environment
#MMPMID27092135
Berjeaud JM
; Chevalier S
; Schlusselhuber M
; Portier E
; Loiseau C
; Aucher W
; Lesouhaitier O
; Verdon J
Front Microbiol
2016[]; 7
(?): 486
PMID27092135
show ga
Legionella pneumophila, the major causative agent of Legionnaires' disease, is
found in freshwater environments in close association with free-living amoebae
and multispecies biofilms, leading to persistence, spread, biocide resistance,
and elevated virulence of the bacterium. Indeed, legionellosis outbreaks are
mainly due to the ability of this bacterium to colonize and persist in water
facilities, despite harsh physical and chemical treatments. However, these
treatments are not totally efficient and, after a lag period, L. pneumophila may
be able to quickly re-colonize these systems. Several natural compounds
(biosurfactants, antimicrobial peptides?) with anti-Legionella properties have
recently been described in the literature, highlighting their specific activities
against this pathogen. In this review, we first consider this hallmark of
Legionella to resist killing, in regard to its biofilm or host-associated life
style. Then, we focus more accurately on natural anti-Legionella molecules
described so far, which could provide new eco-friendly and alternative ways to
struggle against this important pathogen in plumbing.
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