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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Autophagy 2015 ; 11 (10): 1864-77 Nephropedia Template TP
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Common ?-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation #MMPMID26391567
Botbol Y; Patel B; Macian F
Autophagy 2015[Oct]; 11 (10): 1864-77 PMID26391567show ga
Macroautophagy is a cellular process that mediates degradation in the lysosome of cytoplasmic components including proteins and organelles. Previous studies have shown that macroautophagy is induced in activated T cells to regulate organelle homeostasis and the cell's energy metabolism. However, the signaling pathways that initiate and regulate activation-induced macroautophagy in T cells have not been identified. Here, we show that activation-induced macroautophagy in T cells depends on signaling from common ?-chain cytokines. Consequently, inhibition of signaling through JAK3, induced downstream of cytokine receptors containing the common ?-chain, prevents full induction of macroautophagy in activated T cells. Moreover, we found that common ?-chain cytokines are not only required for macroautophagy upregulation during T cell activation but can themselves induce macroautophagy. Our data also show that macroautophagy induction in T cells is associated with an increase of LC3 expression that is mediated by a post-transcriptional mechanism. Overall, our findings unveiled a new role for common ?-chain cytokines as a molecular link between autophagy induction and T-cell activation.