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10.1080/15548627.2015.1089374 http://scihub22266oqcxt.onion/10.1080/15548627.2015.1089374 C4824584!4824584 !26391567     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26391567 &cmd=llinks): Failed to open stream: HTTP request failed! 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Common ?-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation |pdf=|usr=}}{{26391567 }} gab.com Text Common -chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=26391567 #FOAvip Macroautophagy is a cellular process that mediates degradation in the lysosome of cytoplasmic components including proteins and organelles. Previous studies have shown that macroautophagy is induced in activated T cells to regulate organelle homeostasis and the cell's energy metabolism. However, the signaling pathways that initiate and regulate activation-induced macroautophagy in T cells have not been identified. Here, we show that activation-induced macroautophagy in T cells depends on signaling from common ?-chain cytokines. Consequently, inhibition of signaling through JAK3, induced downstream of cytokine receptors containing the common ?-chain, prevents full induction of macroautophagy in activated T cells. Moreover, we found that common ?-chain cytokines are not only required for macroautophagy upregulation during T cell activation but can themselves induce macroautophagy. Our data also show that macroautophagy induction in T cells is associated with an increase of LC3 expression that is mediated by a post-transcriptional mechanism. Overall, our findings unveiled a new role for common ?-chain cytokines as a molecular link between autophagy induction and T-cell activation. Twit Text FOAVip Common -chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=26391567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26391567 #FOAvip English Wikipedia <ref>{{Cite pmid|26391567 }}</ref> Common ?-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation #MMPMID26391567 Botbol Y ; Patel B ; Macian F Autophagy 2015[]; 11 (10 ): 1864-77 PMID26391567 show ga Macroautophagy is a cellular process that mediates degradation in the lysosome of cytoplasmic components including proteins and organelles. Previous studies have shown that macroautophagy is induced in activated T cells to regulate organelle homeostasis and the cell's energy metabolism. However, the signaling pathways that initiate and regulate activation-induced macroautophagy in T cells have not been identified. Here, we show that activation-induced macroautophagy in T cells depends on signaling from common ?-chain cytokines. Consequently, inhibition of signaling through JAK3, induced downstream of cytokine receptors containing the common ?-chain, prevents full induction of macroautophagy in activated T cells. Moreover, we found that common ?-chain cytokines are not only required for macroautophagy upregulation during T cell activation but can themselves induce macroautophagy. Our data also show that macroautophagy induction in T cells is associated with an increase of LC3 expression that is mediated by a post-transcriptional mechanism. Overall, our findings unveiled a new role for common ?-chain cytokines as a molecular link between autophagy induction and T-cell activation. |*Signal Transduction [MESH] |Animals [MESH] |Autophagy/*immunology [MESH] |CD4-Positive T-Lymphocytes/*immunology [MESH] |Cell Communication/*immunology [MESH] |Cytokines/*metabolism [MESH] |Female [MESH] |Lymphocyte Activation/*immunology [MESH] |Mice, Inbred C57BL [MESH]Common ?-chain cytokine signaling is required for macroautophagy induc(epmc).pdf DeepDyve Pubget Overpricing