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10.1080/15548627.2015.1086522 http://scihub22266oqcxt.onion/10.1080/15548627.2015.1086522 C4824578!4824578!26325487     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2015 ; 11 (10): 1833-48 Nephropedia Template TP {{tp|p=26325487|t=2015. RAB24 facilitates clearance of autophagic compartments during basal conditions |pdf=|usr=}}{{26325487}} gab.com Text RAB24 facilitates clearance of autophagic compartments during basal conditions JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=26325487 #FOAvip RAB24 belongs to a family of small GTPases and has been implicated to function in autophagy. Here we confirm the intracellular localization of RAB24 to autophagic vacuoles with immuno electron microscopy and cell fractionation, and show that prenylation and guanine nucleotide binding are necessary for the targeting of RAB24 to autophagic compartments. Further, we show that RAB24 plays a role in the maturation and/or clearance of autophagic compartments under nutrient-rich conditions, but not during short amino acid starvation. Quantitative electron microscopy shows an increase in the numbers of late autophagic compartments in cells silenced for RAB24, and mRFP-GFP-LC3 probe and autophagy flux experiments indicate that this is due to a hindrance in their clearance. Formation of autophagosomes is shown to be unaffected by RAB24-silencing with siRNA. A defect in aggregate clearance in the absence of RAB24 is also shown in cells forming polyglutamine aggregates. This study places RAB24 function in the termination of the autophagic process under nutrient-rich conditions. Twit Text FOAVip RAB24 facilitates clearance of autophagic compartments during basal conditions ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=26325487 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26325487 #FOAvip English Wikipedia <ref>{{Cite pmid|26325487}}</ref> RAB24 facilitates clearance of autophagic compartments during basal conditions #MMPMID26325487 Ylä-Anttila P; Mikkonen E; Happonen KE; Holland P; Ueno T; Simonsen A; Eskelinen EL Autophagy 2015[Oct]; 11 (10): 1833-48 PMID26325487show ga RAB24 belongs to a family of small GTPases and has been implicated to function in autophagy. Here we confirm the intracellular localization of RAB24 to autophagic vacuoles with immuno electron microscopy and cell fractionation, and show that prenylation and guanine nucleotide binding are necessary for the targeting of RAB24 to autophagic compartments. Further, we show that RAB24 plays a role in the maturation and/or clearance of autophagic compartments under nutrient-rich conditions, but not during short amino acid starvation. Quantitative electron microscopy shows an increase in the numbers of late autophagic compartments in cells silenced for RAB24, and mRFP-GFP-LC3 probe and autophagy flux experiments indicate that this is due to a hindrance in their clearance. Formation of autophagosomes is shown to be unaffected by RAB24-silencing with siRNA. A defect in aggregate clearance in the absence of RAB24 is also shown in cells forming polyglutamine aggregates. This study places RAB24 function in the termination of the autophagic process under nutrient-rich conditions. äRAB24 facilitates clearance of autophagic compartments during basal co(epmc).pdf DeepDyve Pubget Overpricing