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10.1080/15548627.2015.1093718 http://scihub22266oqcxt.onion/10.1080/15548627.2015.1093718 C4824573!4824573!26391226     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2015 ; 11 (11): 2127-9 Nephropedia Template TP {{tp|p=26391226|t=2015. GABARAP-mediated targeting of PI4K2A/PI4KII? to autophagosomes regulates PtdIns4P-dependent autophagosome-lysosome fusion |pdf=|usr=}}{{26391226}} gab.com Text GABARAP-mediated targeting of PI4K2A/PI4KII to autophagosomes regulates PtdIns4P-dependent autophagosome-lysosome fusion JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=26391226 #FOAvip For decades, phosphatidylinositol 4-phosphate (PtdIns4P) was considered primarily as a precursor in the synthesis of phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P2). More recently, specific functions for PtdIns4P itself have been identified, particularly in the regulation of intracellular membrane trafficking. PI4K2A/PI4KII? (phosphatidylinositol 4-kinase type 2 ?), one of the 4 enzymes that catalyze PtdIns4P production in mammalian cells, promotes vesicle formation from the trans-Golgi network (TGN) and endosomes. We recently identified a novel function for PI4K2A-derived PtdIns4P, as a facilitator of autophagosome-lysosome (A-L) fusion. We further showed that that this function requires the presence of the autophagic adaptor protein GABARAP (GABA[A] receptor-associated protein), which binds to PI4K2A and recruits it to autophagosomes. The mechanism whereby GABARAP-PI4K2A-PtdIns4P promotes A-L fusion remains to be defined. Based on other examples of phosphoinositide involvement in membrane trafficking, we speculate that it acts by recruiting elements of the membrane docking and fusion machinery. Twit Text FOAVip GABARAP-mediated targeting of PI4K2A/PI4KII to autophagosomes regulates PtdIns4P-dependent autophagosome-lysosome fusion ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=26391226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26391226 #FOAvip English Wikipedia <ref>{{Cite pmid|26391226}}</ref> GABARAP-mediated targeting of PI4K2A/PI4KII? to autophagosomes regulates PtdIns4P-dependent autophagosome-lysosome fusion #MMPMID26391226 Albanesi J; Wang H; Sun HQ; Levine B; Yin H Autophagy 2015[Nov]; 11 (11): 2127-9 PMID26391226show ga For decades, phosphatidylinositol 4-phosphate (PtdIns4P) was considered primarily as a precursor in the synthesis of phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P2). More recently, specific functions for PtdIns4P itself have been identified, particularly in the regulation of intracellular membrane trafficking. PI4K2A/PI4KII? (phosphatidylinositol 4-kinase type 2 ?), one of the 4 enzymes that catalyze PtdIns4P production in mammalian cells, promotes vesicle formation from the trans-Golgi network (TGN) and endosomes. We recently identified a novel function for PI4K2A-derived PtdIns4P, as a facilitator of autophagosome-lysosome (A-L) fusion. We further showed that that this function requires the presence of the autophagic adaptor protein GABARAP (GABA[A] receptor-associated protein), which binds to PI4K2A and recruits it to autophagosomes. The mechanism whereby GABARAP-PI4K2A-PtdIns4P promotes A-L fusion remains to be defined. Based on other examples of phosphoinositide involvement in membrane trafficking, we speculate that it acts by recruiting elements of the membrane docking and fusion machinery. äGABARAP-mediated targeting of PI4K2A/PI4KII? to autophagosomes regulat(epmc).pdf DeepDyve Pubget Overpricing