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10.1152/ajprenal.00365.2015 http://scihub22266oqcxt.onion/10.1152/ajprenal.00365.2015 C4824143!4824143!26739888     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2016 ; 310 (7): F596-606 Nephropedia Template TP {{tp|p=26739888|t=2016. TGF-? signaling in the kidney: profibrotic and protective effects |pdf=|usr=}}{{26739888}} gab.com Text TGF- signaling in the kidney: profibrotic and protective effects JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26739888 #FOAvip Transforming growth factor-? (TGF-?) is generally considered as a central mediator of fibrotic diseases. Indeed, much focus has been placed on inhibiting TGF-? and its downstream targets as ideal therapeutic strategies. However, pharmacological blockade of TGF-? has not yet translated into successful therapy for humans, which may be due to pleiotropic effects of TGF-? signaling. Equally, TGF-? signaling as a protective response in kidney injury has been relatively underexplored. An emerging body of evidence from experimental kidney disease models indicates multifunctionality of TGF-? capable of inducing profibrotic and protective effects. This review discusses recent advances highlighting the diverse roles of TGF-? in promoting not only renal fibrosis but also protective responses of TGF-? signaling. We review, in particular, growing evidence that supports protective effects of TGF-? by mechanisms which include inhibiting inflammation and induction of autophagy. Additional detailed studies are required to fully understand the diverse mechanisms of TGF-? actions in renal fibrosis and inflammation that will likely direct toward effective antifibrotic therapies. Twit Text FOAVip TGF- signaling in the kidney: profibrotic and protective effects ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26739888 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26739888 #FOAvip English Wikipedia <ref>{{Cite pmid|26739888}}</ref> TGF-? signaling in the kidney: profibrotic and protective effects #MMPMID26739888 Sureshbabu A; Muhsin SA; Choi ME Am J Physiol Renal Physiol 2016[Apr]; 310 (7): F596-606 PMID26739888show ga Transforming growth factor-? (TGF-?) is generally considered as a central mediator of fibrotic diseases. Indeed, much focus has been placed on inhibiting TGF-? and its downstream targets as ideal therapeutic strategies. However, pharmacological blockade of TGF-? has not yet translated into successful therapy for humans, which may be due to pleiotropic effects of TGF-? signaling. Equally, TGF-? signaling as a protective response in kidney injury has been relatively underexplored. An emerging body of evidence from experimental kidney disease models indicates multifunctionality of TGF-? capable of inducing profibrotic and protective effects. This review discusses recent advances highlighting the diverse roles of TGF-? in promoting not only renal fibrosis but also protective responses of TGF-? signaling. We review, in particular, growing evidence that supports protective effects of TGF-? by mechanisms which include inhibiting inflammation and induction of autophagy. Additional detailed studies are required to fully understand the diverse mechanisms of TGF-? actions in renal fibrosis and inflammation that will likely direct toward effective antifibrotic therapies. äTGF-? signaling in the kidney: profibrotic and protective effects (epmc).pdf DeepDyve Pubget Overpricing