Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27010856
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cell+Death+Dis
2016 ; 7
(3
): e2155
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Downregulation of renal tubular Wnt/?-catenin signaling by Dickkopf-3 induces
tubular cell death in proteinuric nephropathy
#MMPMID27010856
Wong DW
; Yiu WH
; Wu HJ
; Li RX
; Liu Y
; Chan KW
; Leung JC
; Chan LY
; Lai KN
; Tang SC
Cell Death Dis
2016[Mar]; 7
(3
): e2155
PMID27010856
show ga
Studies on the role of Wnt/?-catenin signaling in different forms of kidney
disease have yielded discrepant results. Here, we report the biphasic change of
renal ?-catenin expression in mice with overload proteinuria in which ?-catenin
was upregulated at the early stage (4 weeks after disease induction) but
abrogated at the late phase (8 weeks). Acute albuminuria was observed at 1 week
after bovine serum albumin injection, followed by partial remission at 4 weeks
that coincided with overexpression of renal tubular ?-catenin. Interestingly, a
rebound in albuminuria at 8 weeks was accompanied by downregulated tubular
?-catenin expression and heightened tubular apoptosis. In addition, there was an
inverse relationship between Dickkopf-3 (Dkk-3) and renal tubular ?-catenin
expression at these time points. In vitro, a similar trend in ?-catenin
expression was observed in human kidney-2 (HK-2) cells with acute (upregulation)
and prolonged (downregulation) exposure to albumin. Induction of a proapoptotic
phenotype by albumin was significantly enhanced by silencing ?-catenin in HK-2
cells. Finally, Dkk-3 expression and secretion was increased after prolonged
exposure to albumin, leading to the suppression of intracellular ?-catenin
signaling pathway. The effect of Dkk-3 on ?-catenin signaling was confirmed by
incubation with exogenous Dkk-3 in HK-2 cells. Taken together, these data suggest
that downregulation of tubular ?-catenin signaling induced by Dkk-3 has a
detrimental role in chronic proteinuria, partially through the increase in
apoptosis.
|*Apoptosis
[MESH]
|*Wnt Signaling Pathway
[MESH]
|Adaptor Proteins, Signal Transducing
[MESH]
|Animals
[MESH]
|Cell Line
[MESH]
|Chemokines
[MESH]
|Gene Expression Regulation
[MESH]
|Humans
[MESH]
|Intercellular Signaling Peptides and Proteins/genetics/*metabolism
[MESH]
free
free
free
