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10.1097/PGP.0000000000000233 http://scihub22266oqcxt.onion/10.1097/PGP.0000000000000233 C4823869!4823869 !26367784     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26367784 &cmd=llinks): Failed to open stream: HTTP request failed! 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Stromal Clues in Endometrial Carcinoma: Loss of Expression of ?-Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptor |pdf=|usr=}}{{26367784 }} gab.com Text Stromal Clues in Endometrial Carcinoma: Loss of Expression of -Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptor JO: Int J Gynecol Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26367784 #FOAvip Epithelial-stroma interactions in the endometrium are known to be responsible for physiological functions and emergence of several pathologic lesions. Periglandular stromal cells act on endometrial cells in a paracrine manner through sex hormones. In this study, we immunohistochemically evaluated the expression of epithelial-mesenchymal transition regulators (SNAIL/SLUG, TWIST, ZEB1), adhesion molecules (?-catenin and E-cadhenin), estrogen (ER)-progesterone (PR) receptor and their correlation with each other in 30 benign, 148 hyperplastic (EH), and 101 endometrioid-type endometrial carcinoma (EC) endometria. In the epithelial component, loss of expression in E-cadherin, ER and PR, and overexpression of TWIST and ZEB1 were significantly higher in EC than in EH (P<0.01). In the periglandular stromal component, ?-catenin and SNAIL/SLUG expression were significantly higher in normal endometrium and simple without atypical EH compared with complex atypical EH and EC (P<0.01). In addition, periglandular stromal TWIST expression was significantly higher in EH group compared with EC (P<0.05). There was significantly negative correlation between ?-catenin and ER, TWIST and ER, and TWIST and PR in hyperplastic and carcinomatous glandular epithelium, whereas there was a significantly positive correlation between ?-catenin and SNAIL-SLUG, ?-catenin and TWIST, ?-catenin and ER, ?-catenin and PR, SNAIL-SLUG and ER, SNAIL-SLUG and PR, TWIST and ER, TWIST and PR, in periglandular/cancer-associated stromal cells (P<0.01). In conclusion, the pattern of positive and negative correlations in the expression of epithelial-mesenchymal transition regulators (SNAIL-SLUG and TWIST), sex hormone receptors (ER and PR), and ?-catenin between ECs and hyperplasia, as well as between epithelium and stroma herein, is suggestive of a significant role for these proteins and their underlying molecular processes in the development of endometrial carcinomas. Twit Text FOAVip Stromal Clues in Endometrial Carcinoma: Loss of Expression of -Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptor ????Int J Gynecol Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26367784 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26367784 #FOAvip English Wikipedia <ref>{{Cite pmid|26367784 }}</ref> Stromal Clues in Endometrial Carcinoma: Loss of Expression of ?-Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptor #MMPMID26367784 Senol S ; Sayar I ; Ceyran AB ; Ibiloglu I ; Akalin I ; Firat U ; Kosemetin D ; Engin Zerk P ; Aydin A Int J Gynecol Pathol 2016[May]; 35 (3 ): 238-48 PMID26367784 show ga Epithelial-stroma interactions in the endometrium are known to be responsible for physiological functions and emergence of several pathologic lesions. Periglandular stromal cells act on endometrial cells in a paracrine manner through sex hormones. In this study, we immunohistochemically evaluated the expression of epithelial-mesenchymal transition regulators (SNAIL/SLUG, TWIST, ZEB1), adhesion molecules (?-catenin and E-cadhenin), estrogen (ER)-progesterone (PR) receptor and their correlation with each other in 30 benign, 148 hyperplastic (EH), and 101 endometrioid-type endometrial carcinoma (EC) endometria. In the epithelial component, loss of expression in E-cadherin, ER and PR, and overexpression of TWIST and ZEB1 were significantly higher in EC than in EH (P<0.01). In the periglandular stromal component, ?-catenin and SNAIL/SLUG expression were significantly higher in normal endometrium and simple without atypical EH compared with complex atypical EH and EC (P<0.01). In addition, periglandular stromal TWIST expression was significantly higher in EH group compared with EC (P<0.05). There was significantly negative correlation between ?-catenin and ER, TWIST and ER, and TWIST and PR in hyperplastic and carcinomatous glandular epithelium, whereas there was a significantly positive correlation between ?-catenin and SNAIL-SLUG, ?-catenin and TWIST, ?-catenin and ER, ?-catenin and PR, SNAIL-SLUG and ER, SNAIL-SLUG and PR, TWIST and ER, TWIST and PR, in periglandular/cancer-associated stromal cells (P<0.01). In conclusion, the pattern of positive and negative correlations in the expression of epithelial-mesenchymal transition regulators (SNAIL-SLUG and TWIST), sex hormone receptors (ER and PR), and ?-catenin between ECs and hyperplasia, as well as between epithelium and stroma herein, is suggestive of a significant role for these proteins and their underlying molecular processes in the development of endometrial carcinomas. |Antigens, CD [MESH] |Biomarkers, Tumor/*metabolism [MESH] |Cadherins/metabolism [MESH] |Carcinoma, Endometrioid/metabolism/*pathology [MESH] |Endometrial Neoplasms/metabolism/*pathology [MESH] |Endometrium/metabolism/pathology [MESH] |Epithelial-Mesenchymal Transition [MESH] |Female [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Receptors, Estrogen/metabolism [MESH] |Receptors, Progesterone/metabolism [MESH] |Stromal Cells/metabolism/pathology [MESH] |Tissue Array Analysis [MESH]Stromal Clues in Endometrial Carcinoma: Loss of Expression of ?-Cateni(epmc).pdf DeepDyve Pubget Overpricing