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10.1038/srep23968 http://scihub22266oqcxt.onion/10.1038/srep23968 C4823739!4823739 !27052477     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27052477 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 23968 Nephropedia Template TP {{tp|p=27052477 |t=2016. Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and ?-catenin Signaling |pdf=|usr=}}{{27052477 }} gab.com Text Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and -catenin Signaling JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27052477 #FOAvip Quercetin, a flavonoid found in a wide variety of plants and presented in human diet, displays promising potential in preventing kidney fibroblast activation. However, whether quercetin can ameliorate kidney fibrosis in mice with obstructive nephropathy and the underlying mechanisms remain to be further elucidated. In this study, we found that administration of quercetin could largely ameliorate kidney interstitial fibrosis and macrophage accumulation in the kidneys with obstructive nephropathy. MTORC1, mTORC2, ?-catenin as well as Smad signaling were activated in the obstructive kidneys, whereas quercetin could markedly reduce their abundance except Smad3 phosphorylation. In cultured NRK-49F cells, quercetin could inhibit ?-SMA and fibronectin (FN) expression induced by TGF?1 treatment. MTORC1, mTORC2, ?-catenin and Smad signaling pathways were stimulated by TGF?1 at a time dependent manner. Similar to those findings in the obstructive kidneys, mTORC1, mTORC2 and ?-catenin, but not Smad signaling pathways were remarkably blocked by quercetin treatment. Together, these results suggest that quercetin inhibits fibroblast activation and kidney fibrosis involving a combined inhibition of mTOR and ?-catenin signaling transduction, which may act as a therapeutic candidate for patients with chronic kidney diseases. Twit Text FOAVip Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and -catenin Signaling ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27052477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27052477 #FOAvip English Wikipedia <ref>{{Cite pmid|27052477 }}</ref> Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and ?-catenin Signaling #MMPMID27052477 Ren J ; Li J ; Liu X ; Feng Y ; Gui Y ; Yang J ; He W ; Dai C Sci Rep 2016[Apr]; 6 (ä): 23968 PMID27052477 show ga Quercetin, a flavonoid found in a wide variety of plants and presented in human diet, displays promising potential in preventing kidney fibroblast activation. However, whether quercetin can ameliorate kidney fibrosis in mice with obstructive nephropathy and the underlying mechanisms remain to be further elucidated. In this study, we found that administration of quercetin could largely ameliorate kidney interstitial fibrosis and macrophage accumulation in the kidneys with obstructive nephropathy. MTORC1, mTORC2, ?-catenin as well as Smad signaling were activated in the obstructive kidneys, whereas quercetin could markedly reduce their abundance except Smad3 phosphorylation. In cultured NRK-49F cells, quercetin could inhibit ?-SMA and fibronectin (FN) expression induced by TGF?1 treatment. MTORC1, mTORC2, ?-catenin and Smad signaling pathways were stimulated by TGF?1 at a time dependent manner. Similar to those findings in the obstructive kidneys, mTORC1, mTORC2 and ?-catenin, but not Smad signaling pathways were remarkably blocked by quercetin treatment. Together, these results suggest that quercetin inhibits fibroblast activation and kidney fibrosis involving a combined inhibition of mTOR and ?-catenin signaling transduction, which may act as a therapeutic candidate for patients with chronic kidney diseases. |Animals [MESH] |Antioxidants/pharmacology [MESH] |Blotting, Western [MESH] |Cell Line [MESH] |Cytokines/metabolism [MESH] |Fibroblasts/cytology/*drug effects/metabolism [MESH] |Fibronectins/metabolism [MESH] |Fibrosis/genetics/metabolism/prevention & control [MESH] |Gene Expression/drug effects [MESH] |Kidney/*drug effects/metabolism/pathology [MESH] |Macrophages/drug effects/metabolism [MESH] |Male [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Mechanistic Target of Rapamycin Complex 2 [MESH] |Mice [MESH] |Multiprotein Complexes/metabolism [MESH] |Quercetin/*pharmacology [MESH] |Rats [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Signal Transduction/*drug effects [MESH] |Smad Proteins/metabolism [MESH] |Snail Family Transcription Factors/genetics/metabolism [MESH] |TOR Serine-Threonine Kinases/*metabolism [MESH] |Transforming Growth Factor beta1/pharmacology [MESH] |Twist Transcription Factors/genetics/metabolism [MESH]Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving(epmc).pdf DeepDyve Pubget Overpricing