Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.14814/phy2.12727 http://scihub22266oqcxt.onion/10.14814/phy2.12727 C4823602!4823602 !26997628     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26997628 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Physiol+Rep 2016 ; 4 (5 ): ä Nephropedia Template TP {{tp|p=26997628 |t=2016. Aberrant nonfibrotic parenchyma in idiopathic pulmonary fibrosis is correlated with decreased ?-catenin inhibition and increased Wnt5a/b interaction |pdf=|usr=}}{{26997628 }} gab.com Text Aberrant nonfibrotic parenchyma in idiopathic pulmonary fibrosis is correlated with decreased -catenin inhibition and increased Wnt5a/b interaction JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=26997628 #FOAvip Idiopathic pulmonary fibrosis (IPF), an insidious disease with grave prognosis, is characterized by heterogeneous fibrosis with densely fibrotic areas surrounded by nonfibrotic normal-looking tissue, believed to reflect a temporal development. The etiology is incompletely elucidated, but aberrant wound healing is believed to be involved. Embryonic signaling pathways, including Wnt signaling, are reactivated in wound healing, and we therefore aimed to investigate Wnt signaling, and hypothesized that Wnt signaling would correspond to degree of fibrosis. Material from 10 patients with IPF were included (four diagnostic biopsies and six donated lungs) and compared to healthy controls (n = 7). We investigated markers of Wnt signaling (?-catenin, Wnt3a, ICAT, Wnt5a/b, DAAM1 and NLK) histologically in lung parenchyma with variable degree of fibrosis. Our results suggest that Wnt signaling is significantly altered (P < 0.05) already in normal-looking parenchyma. The expression of Wnt3a and ICAT decreased (both P < 0.01) in IPF compared to healthy lungs, whereas ?-catenin, Wnt5a/b, DAAM1 and NLK increased (P < 0.05 for all). ICAT is further decreased in dense fibrosis compared to normal-looking parenchyma in IPF (P < 0.001). On the basis of our results, we conclude that from a Wnt perspective, there is no normal parenchyma in IPF, and Wnt signaling corresponds to degree of fibrosis. In addition, ?-catenin and Wnt5a appears coupled, and decreased inhibition of ?-catenin may be involved. We suggest that the interaction between ?-catenin, ICAT, and Wnt5a/b may represent an important research area and potential target for therapeutic intervention. Twit Text FOAVip Aberrant nonfibrotic parenchyma in idiopathic pulmonary fibrosis is correlated with decreased -catenin inhibition and increased Wnt5a/b interaction ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=26997628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26997628 #FOAvip English Wikipedia <ref>{{Cite pmid|26997628 }}</ref> Aberrant nonfibrotic parenchyma in idiopathic pulmonary fibrosis is correlated with decreased ?-catenin inhibition and increased Wnt5a/b interaction #MMPMID26997628 Rydell-Törmänen K ; Zhou XH ; Hallgren O ; Einarsson J ; Eriksson L ; Andersson-Sjöland A ; Westergren-Thorsson G Physiol Rep 2016[Mar]; 4 (5 ): ä PMID26997628 show ga Idiopathic pulmonary fibrosis (IPF), an insidious disease with grave prognosis, is characterized by heterogeneous fibrosis with densely fibrotic areas surrounded by nonfibrotic normal-looking tissue, believed to reflect a temporal development. The etiology is incompletely elucidated, but aberrant wound healing is believed to be involved. Embryonic signaling pathways, including Wnt signaling, are reactivated in wound healing, and we therefore aimed to investigate Wnt signaling, and hypothesized that Wnt signaling would correspond to degree of fibrosis. Material from 10 patients with IPF were included (four diagnostic biopsies and six donated lungs) and compared to healthy controls (n = 7). We investigated markers of Wnt signaling (?-catenin, Wnt3a, ICAT, Wnt5a/b, DAAM1 and NLK) histologically in lung parenchyma with variable degree of fibrosis. Our results suggest that Wnt signaling is significantly altered (P < 0.05) already in normal-looking parenchyma. The expression of Wnt3a and ICAT decreased (both P < 0.01) in IPF compared to healthy lungs, whereas ?-catenin, Wnt5a/b, DAAM1 and NLK increased (P < 0.05 for all). ICAT is further decreased in dense fibrosis compared to normal-looking parenchyma in IPF (P < 0.001). On the basis of our results, we conclude that from a Wnt perspective, there is no normal parenchyma in IPF, and Wnt signaling corresponds to degree of fibrosis. In addition, ?-catenin and Wnt5a appears coupled, and decreased inhibition of ?-catenin may be involved. We suggest that the interaction between ?-catenin, ICAT, and Wnt5a/b may represent an important research area and potential target for therapeutic intervention. |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Female [MESH] |Humans [MESH] |Idiopathic Pulmonary Fibrosis/*metabolism/*pathology [MESH] |Lung/cytology/*metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Protein Binding/physiology [MESH] |Proto-Oncogene Proteins/*biosynthesis [MESH] |Wnt Proteins/*biosynthesis [MESH] |Wnt-5a Protein [MESH]Aberrant nonfibrotic parenchyma in idiopathic pulmonary fibrosis is co(epmc).pdf DeepDyve Pubget Overpricing