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10.1016/j.celrep.2016.02.038 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.02.038 C4823467!4823467 !26947065     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26947065 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2016 ; 14 (10 ): 2451-62 Nephropedia Template TP {{tp|p=26947065 |t=2016. Localized Translation of gurken/TGF-? mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies |pdf=|usr=}}{{26947065 }} gab.com Text Localized Translation of gurken/TGF- mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26947065 #FOAvip In Drosophila oocytes, gurken/TGF-? mRNA is essential for establishing the future embryonic axes. gurken remains translationally silent during transport from its point of synthesis in nurse cells to its final destination in the oocyte, where it associates with the edge of processing bodies. Here we show that, in nurse cells, gurken is kept translationally silent by the lack of sufficient Orb/CPEB, its translational activator. Processing bodies in nurse cells have a similar protein complement and ultrastructure to those in the oocyte, but they markedly less Orb and do not associate with gurken mRNA. Ectopic expression of Orb in nurse cells at levels similar to the wild-type oocyte dorso-anterior corner at mid-oogenesis is sufficient to cause gurken mRNA to associate with processing bodies and translate prematurely. We propose that controlling the spatial distribution of translational activators is a fundamental mechanism for regulating localized translation. Twit Text FOAVip Localized Translation of gurken/TGF- mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26947065 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26947065 #FOAvip English Wikipedia <ref>{{Cite pmid|26947065 }}</ref> Localized Translation of gurken/TGF-? mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies #MMPMID26947065 Davidson A ; Parton RM ; Rabouille C ; Weil TT ; Davis I Cell Rep 2016[Mar]; 14 (10 ): 2451-62 PMID26947065 show ga In Drosophila oocytes, gurken/TGF-? mRNA is essential for establishing the future embryonic axes. gurken remains translationally silent during transport from its point of synthesis in nurse cells to its final destination in the oocyte, where it associates with the edge of processing bodies. Here we show that, in nurse cells, gurken is kept translationally silent by the lack of sufficient Orb/CPEB, its translational activator. Processing bodies in nurse cells have a similar protein complement and ultrastructure to those in the oocyte, but they markedly less Orb and do not associate with gurken mRNA. Ectopic expression of Orb in nurse cells at levels similar to the wild-type oocyte dorso-anterior corner at mid-oogenesis is sufficient to cause gurken mRNA to associate with processing bodies and translate prematurely. We propose that controlling the spatial distribution of translational activators is a fundamental mechanism for regulating localized translation. |Animals [MESH] |DEAD-box RNA Helicases/genetics/metabolism [MESH] |Drosophila Proteins/genetics/*metabolism [MESH] |Drosophila/*metabolism [MESH] |Female [MESH] |Gene Expression Regulation, Developmental [MESH] |Genes, Reporter [MESH] |In Situ Hybridization, Fluorescence [MESH] |Microscopy, Fluorescence [MESH] |Oocytes/cytology/metabolism [MESH] |Oogenesis [MESH] |RNA, Messenger/metabolism [MESH] |RNA-Binding Proteins/*metabolism [MESH]Localized Translation of gurken/TGF-? mRNA during Axis Specification I(epmc).pdf DeepDyve Pubget Overpricing