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2016 ; 10
(ä): 30
Nephropedia Template TP
gab.com Text
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English Wikipedia
Making Waves in the Brain: What Are Oscillations, and Why Modulating Them Makes
Sense for Brain Injury
#MMPMID27092062
Pevzner A
; Izadi A
; Lee DJ
; Shahlaie K
; Gurkoff GG
Front Syst Neurosci
2016[]; 10
(ä): 30
PMID27092062
show ga
Traumatic brain injury (TBI) can result in persistent cognitive, behavioral and
emotional deficits. However, the vast majority of patients are not chronically
hospitalized; rather they have to manage their disabilities once they are
discharged to home. Promoting recovery to pre-injury level is important from a
patient care as well as a societal perspective. Electrical neuromodulation is one
approach that has shown promise in alleviating symptoms associated with
neurological disorders such as in Parkinson's disease (PD) and epilepsy.
Consistent with this perspective, both animal and clinical studies have revealed
that TBI alters physiological oscillatory rhythms. More recently several studies
demonstrated that low frequency stimulation improves cognitive outcome in models
of TBI. Specifically, stimulation of the septohippocampal circuit in the theta
frequency entrained oscillations and improved spatial learning following TBI. In
order to evaluate the potential of electrical deep brain stimulation for clinical
translation we review the basic neurophysiology of oscillations, their role in
cognition and how they are changed post-TBI. Furthermore, we highlight several
factors for future pre-clinical and clinical studies to consider, with the hope
that it will promote a hypothesis driven approach to subsequent experimental
designs and ultimately successful translation to improve outcome in patients with
TBI.