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10.1016/j.gene.2016.02.019 http://scihub22266oqcxt.onion/10.1016/j.gene.2016.02.019 C4823161!4823161!26892498     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene 2016 ; 584 (2): 111-9 Nephropedia Template TP {{tp|p=26892498|t=2016. SALL4, the missing link between stem cells, development and cancer |pdf=|usr=}}{{26892498}} gab.com Text SALL4, the missing link between stem cells, development and cancer JO: Gene http://www.kidney.de/pget.php?&tw=1&pmid=26892498 #FOAvip There is a growing body of evidence supporting that cancer cells share many similarities with embryonic stem cells (ESCs). For example, aggressive cancers and ESCs share a common gene expression signature that includes hundreds of genes. Since ESC genes are not present in most adult tissues, they could be ideal candidate targets for cancer-specific diagnosis and treatment. This is an exciting cancer-targeting model. The major hurdle to test this model is to identify the key factors/pathway(s) within ESCs that are responsible for the cancer phenotype. SALL4 is one of few genes that can establish this link. The first publication of SALL4 is on its mutation in a human inherited disorder with multiple developmental defects. Since then, over 300 papers have been published on various aspects of this gene in stem cells, development, and cancers. This review aims to summarize our current knowledge of SALL4, including a SALL4-based approach to classify and target cancers. Many questions about this important gene still remain unanswered, specifically, on how this gene regulates cell fates at a molecular level. Understanding SALL4?s molecular functions will allow development of specific targeted approaches in the future. Twit Text FOAVip SALL4, the missing link between stem cells, development and cancer ????Gene http://www.kidney.de/pget.php?&tw=1&pmid=26892498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26892498 #FOAvip English Wikipedia <ref>{{Cite pmid|26892498}}</ref> SALL4, the missing link between stem cells, development and cancer #MMPMID26892498 Tatetsu H; Kong NR; Chong G; Amabile G; Tenen DG; Chai L Gene 2016[Jun]; 584 (2): 111-9 PMID26892498show ga There is a growing body of evidence supporting that cancer cells share many similarities with embryonic stem cells (ESCs). For example, aggressive cancers and ESCs share a common gene expression signature that includes hundreds of genes. Since ESC genes are not present in most adult tissues, they could be ideal candidate targets for cancer-specific diagnosis and treatment. This is an exciting cancer-targeting model. The major hurdle to test this model is to identify the key factors/pathway(s) within ESCs that are responsible for the cancer phenotype. SALL4 is one of few genes that can establish this link. The first publication of SALL4 is on its mutation in a human inherited disorder with multiple developmental defects. Since then, over 300 papers have been published on various aspects of this gene in stem cells, development, and cancers. This review aims to summarize our current knowledge of SALL4, including a SALL4-based approach to classify and target cancers. Many questions about this important gene still remain unanswered, specifically, on how this gene regulates cell fates at a molecular level. Understanding SALL4?s molecular functions will allow development of specific targeted approaches in the future. äSALL4, the missing link between stem cells, development and cancer (epmc).pdf DeepDyve Pubget Overpricing