Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.18632/oncotarget.6787 http://scihub22266oqcxt.onion/10.18632/oncotarget.6787 C4823025!4823025!26734837     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (3): 2155-8 Nephropedia Template TP {{tp|p=26734837|t=2016. Click chemistry, 3D-printing, and omics: the future of drug development |pdf=|usr=}}{{26734837}} gab.com Text Click chemistry, 3D-printing, and omics: the future of drug development JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26734837 #FOAvip Genomics is a disruptive technology, having revealed that cancers are tremendously complex and differ from patient to patient. Therefore, conventional treatment approaches fit poorly with genomic reality. Furthermore, it is likely that this type of complexity will also be observed in other illnesses. Precision medicine has been posited as a way to better target disease-related aberrations, but developing drugs and tailoring therapy to each patient's complicated problem is a major challenge. One solution would be to match patients to existing compounds based on in silico modeling. However, optimization of complex therapy will eventually require designing compounds for patients using computer modeling and just-in-time production, perhaps achievable in the future by three-dimensional (3D) printing. Indeed, 3D printing is potentially transformative by virtue of its ability to rapidly generate almost limitless numbers of objects that previously required manufacturing facilities. Companies are already endeavoring to develop affordable 3D printers for home use. An attractive, but as yet scantily explored, application is to place chemical design and production under digital control. This could be accomplished by utilizing a 3D printer to initiate chemical reactions, and print the reagents and/or the final compounds directly. Of interest, the Food and Drug Administration (FDA) has recently approved a 3D printed drug?levetiracetam?indicated for seizures. Further, it is now increasingly clear that biologic materials?tissues, and eventually organs?can also be ?printed.? In the near future, it is plausible that high-throughput computing may be deployed to design customized drugs, which will reshape medicine. Twit Text FOAVip Click chemistry, 3D-printing, and omics: the future of drug development ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26734837 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26734837 #FOAvip English Wikipedia <ref>{{Cite pmid|26734837}}</ref> Click chemistry, 3D-printing, and omics: the future of drug development #MMPMID26734837 Kurzrock R; Stewart DJ Oncotarget 2016[Jan]; 7 (3): 2155-8 PMID26734837show ga Genomics is a disruptive technology, having revealed that cancers are tremendously complex and differ from patient to patient. Therefore, conventional treatment approaches fit poorly with genomic reality. Furthermore, it is likely that this type of complexity will also be observed in other illnesses. Precision medicine has been posited as a way to better target disease-related aberrations, but developing drugs and tailoring therapy to each patient's complicated problem is a major challenge. One solution would be to match patients to existing compounds based on in silico modeling. However, optimization of complex therapy will eventually require designing compounds for patients using computer modeling and just-in-time production, perhaps achievable in the future by three-dimensional (3D) printing. Indeed, 3D printing is potentially transformative by virtue of its ability to rapidly generate almost limitless numbers of objects that previously required manufacturing facilities. Companies are already endeavoring to develop affordable 3D printers for home use. An attractive, but as yet scantily explored, application is to place chemical design and production under digital control. This could be accomplished by utilizing a 3D printer to initiate chemical reactions, and print the reagents and/or the final compounds directly. Of interest, the Food and Drug Administration (FDA) has recently approved a 3D printed drug?levetiracetam?indicated for seizures. Further, it is now increasingly clear that biologic materials?tissues, and eventually organs?can also be ?printed.? In the near future, it is plausible that high-throughput computing may be deployed to design customized drugs, which will reshape medicine. äClick chemistry, 3D-printing, and omics: the future of drug developmen(epmc).pdf DeepDyve Pubget Overpricing