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10.1126/science.aaa3662 http://scihub22266oqcxt.onion/10.1126/science.aaa3662 C4823017!4823017 !25954009     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25954009 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2015 ; 348 (6235 ): 694-9 Nephropedia Template TP {{tp|p=25954009 |t=2015. Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality |pdf=|usr=}}{{25954009 }} gab.com Text Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25954009 #FOAvip Immunosuppression after measles is known to predispose people to opportunistic infections for a period of several weeks to months. Using population-level data, we show that measles has a more prolonged effect on host resistance, extending over 2 to 3 years. We find that nonmeasles infectious disease mortality in high-income countries is tightly coupled to measles incidence at this lag, in both the pre- and post-vaccine eras. We conclude that long-term immunologic sequelae of measles drive interannual fluctuations in nonmeasles deaths. This is consistent with recent experimental work that attributes the immunosuppressive effects of measles to depletion of B and T lymphocytes. Our data provide an explanation for the long-term benefits of measles vaccination in preventing all-cause infectious disease. By preventing measles-associated immune memory loss, vaccination protects polymicrobial herd immunity. Twit Text FOAVip Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25954009 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25954009 #FOAvip English Wikipedia <ref>{{Cite pmid|25954009 }}</ref> Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality #MMPMID25954009 Mina MJ ; Metcalf CJ ; de Swart RL ; Osterhaus AD ; Grenfell BT Science 2015[May]; 348 (6235 ): 694-9 PMID25954009 show ga Immunosuppression after measles is known to predispose people to opportunistic infections for a period of several weeks to months. Using population-level data, we show that measles has a more prolonged effect on host resistance, extending over 2 to 3 years. We find that nonmeasles infectious disease mortality in high-income countries is tightly coupled to measles incidence at this lag, in both the pre- and post-vaccine eras. We conclude that long-term immunologic sequelae of measles drive interannual fluctuations in nonmeasles deaths. This is consistent with recent experimental work that attributes the immunosuppressive effects of measles to depletion of B and T lymphocytes. Our data provide an explanation for the long-term benefits of measles vaccination in preventing all-cause infectious disease. By preventing measles-associated immune memory loss, vaccination protects polymicrobial herd immunity. |*Child Mortality [MESH] |*Immunomodulation [MESH] |B-Lymphocytes/immunology [MESH] |Child [MESH] |Child, Preschool [MESH] |England/epidemiology [MESH] |Female [MESH] |Humans [MESH] |Immunologic Memory [MESH] |Incidence [MESH] |Lymphocyte Depletion [MESH] |Male [MESH] |Measles Vaccine/administration & dosage/*immunology [MESH] |Measles/*epidemiology/*immunology/prevention & control [MESH] |Opportunistic Infections/immunology/*mortality/*prevention & control [MESH] |T-Lymphocytes/immunology [MESH] |Time Factors [MESH] |United States/epidemiology [MESH] |Vaccination [MESH]Long-term measles-induced immunomodulation increases overall childhood(epmc).pdf DeepDyve Pubget Overpricing