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10.1073/pnas.1602264113 http://scihub22266oqcxt.onion/10.1073/pnas.1602264113 C4822583!4822583 !26976564     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26976564 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition |pdf=|usr=}}{{26976564 }} gab.com Text Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26976564 #FOAvip During the mitochondrial permeability transition, a large channel in the inner mitochondrial membrane opens, leading to the loss of multiple mitochondrial solutes and cell death. Key triggers include excessive reactive oxygen species and mitochondrial calcium overload, factors implicated in neuronal and cardiac pathophysiology. Examining the differential behavior of mitochondrial Ca(2+) overload in Drosophila versus human cells allowed us to identify a gene, MCUR1, which, when expressed in Drosophila cells, conferred permeability transition sensitive to electrophoretic Ca(2+) uptake. Conversely, inhibiting MCUR1 in mammalian cells increased the Ca(2+) threshold for inducing permeability transition. The effect was specific to the permeability transition induced by Ca(2+), and such resistance to overload translated into improved cell survival. Thus, MCUR1 expression regulates the Ca(2+) threshold required for permeability transition. Twit Text FOAVip Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26976564 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26976564 #FOAvip English Wikipedia <ref>{{Cite pmid|26976564 }}</ref> Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition #MMPMID26976564 Chaudhuri D ; Artiga DJ ; Abiria SA ; Clapham DE Proc Natl Acad Sci U S A 2016[Mar]; 113 (13 ): E1872-80 PMID26976564 show ga During the mitochondrial permeability transition, a large channel in the inner mitochondrial membrane opens, leading to the loss of multiple mitochondrial solutes and cell death. Key triggers include excessive reactive oxygen species and mitochondrial calcium overload, factors implicated in neuronal and cardiac pathophysiology. Examining the differential behavior of mitochondrial Ca(2+) overload in Drosophila versus human cells allowed us to identify a gene, MCUR1, which, when expressed in Drosophila cells, conferred permeability transition sensitive to electrophoretic Ca(2+) uptake. Conversely, inhibiting MCUR1 in mammalian cells increased the Ca(2+) threshold for inducing permeability transition. The effect was specific to the permeability transition induced by Ca(2+), and such resistance to overload translated into improved cell survival. Thus, MCUR1 expression regulates the Ca(2+) threshold required for permeability transition. |Amino Acid Sequence [MESH] |Animals [MESH] |Calcium/*metabolism [MESH] |Cyclophilins/genetics/metabolism [MESH] |Drosophila Proteins/genetics/metabolism [MESH] |Drosophila/cytology/genetics/metabolism [MESH] |Fluoresceins/metabolism [MESH] |Humans [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Mitochondrial Membranes/*metabolism [MESH] |Mitochondrial Proteins/genetics/*metabolism [MESH] |Molecular Sequence Data [MESH] |Myocytes, Cardiac/cytology/metabolism [MESH] |Permeability [MESH] |Rats [MESH]Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calc(epmc).pdf DeepDyve Pubget Overpricing